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2
Normal assembly of 60 S ribosomal subunits is required for the signaling in response to a secretory defect in Saccharomyces cerevisiae.酿酒酵母中60 S核糖体亚基的正常组装是响应分泌缺陷进行信号传导所必需的。
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3
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Ebp2p, yeast homologue of a human protein that interacts with Epstein-Barr virus nuclear antigen 1, is required for pre-rRNA processing and ribosomal subunit assembly.Ebp2p是一种与爱泼斯坦-巴尔病毒核抗原1相互作用的人类蛋白质的酵母同源物，它是前体核糖体RNA加工和核糖体亚基组装所必需的。
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Novel stress-responsive genes EMG1 and NOP14 encode conserved, interacting proteins required for 40S ribosome biogenesis.新型应激反应基因EMG1和NOP14编码40S核糖体生物合成所需的保守相互作用蛋白。
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Functional analysis of Rrp7p, an essential yeast protein involved in pre-rRNA processing and ribosome assembly.Rrp7p的功能分析，Rrp7p是一种参与前体rRNA加工和核糖体组装的必需酵母蛋白。
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本文引用的文献

1
Imp3p and Imp4p, two specific components of the U3 small nucleolar ribonucleoprotein that are essential for pre-18S rRNA processing.Imp3p和Imp4p是U3小核仁核糖核蛋白的两个特定组分，对于前18S核糖体RNA加工至关重要。
Mol Cell Biol. 1999 Aug;19(8):5441-52. doi: 10.1128/MCB.19.8.5441.
2
DNA-binding requirements of the yeast protein Rap1p as selected in silico from ribosomal protein gene promoter sequences.从核糖体蛋白基因启动子序列中通过计算机模拟筛选出的酵母蛋白Rap1p的DNA结合要求。
Bioinformatics. 1999 Apr;15(4):267-77. doi: 10.1093/bioinformatics/15.4.267.
3
Protein kinase C enables the regulatory circuit that connects membrane synthesis to ribosome synthesis in Saccharomyces cerevisiae.蛋白激酶C促成了酿酒酵母中连接膜合成与核糖体合成的调控回路。
J Biol Chem. 1999 May 7;274(19):13235-41. doi: 10.1074/jbc.274.19.13235.
4
Nip7p interacts with Nop8p, an essential nucleolar protein required for 60S ribosome biogenesis, and the exosome subunit Rrp43p.Nip7p与Nop8p相互作用，Nop8p是60S核糖体生物合成所需的一种必需核仁蛋白，Nip7p还与外切体亚基Rrp43p相互作用。
Mol Cell Biol. 1999 Feb;19(2):1518-25. doi: 10.1128/MCB.19.2.1518.
5
Yeast 18S rRNA dimethylase Dim1p: a quality control mechanism in ribosome synthesis?酵母18S rRNA二甲基化酶Dim1p：核糖体合成中的一种质量控制机制？
Mol Cell Biol. 1998 Apr;18(4):2360-70. doi: 10.1128/MCB.18.4.2360.
6
The box H + ACA snoRNAs carry Cbf5p, the putative rRNA pseudouridine synthase.盒H + ACA小核仁RNA携带Cbf5p，即假定的核糖体RNA假尿苷合酶。
Genes Dev. 1998 Feb 15;12(4):527-37. doi: 10.1101/gad.12.4.527.
7
The C-terminal silencing domain of Rap1p is essential for the repression of ribosomal protein genes in response to a defect in the secretory pathway.Rap1p的C末端沉默结构域对于响应分泌途径缺陷时核糖体蛋白基因的抑制至关重要。
Nucleic Acids Res. 1998 Feb 15;26(4):1063-9. doi: 10.1093/nar/26.4.1063.
8
A new nomenclature for the cytoplasmic ribosomal proteins of Saccharomyces cerevisiae.酿酒酵母细胞质核糖体蛋白的新命名法。
Nucleic Acids Res. 1997 Dec 15;25(24):4872-5. doi: 10.1093/nar/25.24.4872.
9
The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases.外泌体：一种保守的真核生物RNA加工复合体，含有多种3'→5'外切核糖核酸酶。
Cell. 1997 Nov 14;91(4):457-66. doi: 10.1016/s0092-8674(00)80432-8.
10
Nucleolar KKE/D repeat proteins Nop56p and Nop58p interact with Nop1p and are required for ribosome biogenesis.核仁KKE/D重复蛋白Nop56p和Nop58p与Nop1p相互作用，是核糖体生物发生所必需的。
Mol Cell Biol. 1997 Dec;17(12):7088-98. doi: 10.1128/MCB.17.12.7088.

RRS1是一个保守的必需基因，它编码酿酒酵母核糖体生物合成所需的一种新型调节蛋白。

RRS1, a conserved essential gene, encodes a novel regulatory protein required for ribosome biogenesis in Saccharomyces cerevisiae.

作者信息

Tsuno A, Miyoshi K, Tsujii R, Miyakawa T, Mizuta K

机构信息

Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, Higashi-Hiroshima 739-8527, Japan.

出版信息

Mol Cell Biol. 2000 Mar;20(6):2066-74. doi: 10.1128/MCB.20.6.2066-2074.2000.

DOI:10.1128/MCB.20.6.2066-2074.2000
PMID:10688653
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC110823/
Abstract

A secretory defect causes specific and significant transcriptional repression of both ribosomal protein and rRNA genes (K. Mizuta and J. R. Warner, Mol. Cell. Biol. 14:2493-2502, 1994), suggesting the coupling of plasma membrane and ribosome syntheses. In order to elucidate the molecular mechanism of the signaling pathway, we isolated a cold-sensitive mutant with a mutation in a gene termed RRS1 (regulator of ribosome synthesis), which appeared to be defective in the signaling pathway. The rrs1-1 mutation greatly reduced transcriptional repression of both rRNA and ribosomal protein genes that is caused by a secretory defect. RRS1 is a novel, essential gene encoding a nuclear protein of 203 amino acid residues that is conserved in eukaryotes. A conditional rrs1-null mutant was constructed by placing RRS1 under the control of the GAL1 promoter. Rrs1p depletion caused defects in processing of pre-rRNA and assembly of ribosomal subunits.

摘要

一种分泌缺陷会导致核糖体蛋白基因和rRNA基因发生特异性且显著的转录抑制（K. 水田和J. R. 华纳，《分子与细胞生物学》14:2493 - 2502，1994年），这表明质膜合成与核糖体合成之间存在偶联关系。为了阐明该信号通路的分子机制，我们分离出了一个冷敏感突变体，其在一个名为RRS1（核糖体合成调节因子）的基因中发生了突变，该突变体在信号通路中似乎存在缺陷。rrs1 - 1突变极大地降低了由分泌缺陷引起的rRNA和核糖体蛋白基因的转录抑制。RRS1是一个新的必需基因，编码一个由203个氨基酸残基组成的核蛋白，该蛋白在真核生物中保守。通过将RRS1置于GAL1启动子的控制之下构建了一个条件性rrs1缺失突变体。Rrs1p的缺失导致前体rRNA加工和核糖体亚基组装出现缺陷。