Baars M A E, van Boxtel M P J, Dijkstra J B, Visser P J, van den Akker M, Verhey F R J, Jolles J
Department of Psychiatry and Neuropsychology, School for Public Health and Primary Care CAPHRI, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
Dement Geriatr Cogn Disord. 2009;27(2):173-81. doi: 10.1159/000200465. Epub 2009 Feb 7.
BACKGROUND/AIMS: In population studies, different mild cognitive impairment (MCI) definitions have been used to predict dementia at a later stage. This study compared predictive values of different MCI definitions for dementia, and the effect of age on the predictive values was investigated.
This study was conducted as part of an ongoing longitudinal study into the determinants of cognitive aging, the Maastricht Aging Study.
MCI best predicted dementia when multiple cognitive domains were considered and subjective complaints were not (sensitivity: 0.66, specificity: 0.78). Age had a strong influence on the sensitivity of MCI for dementia (age 60-70 years: sensitivity = 0.56; age 70-85 years: sensitivity = 0.70).
The inclusion of multiple cognitive domains and participants aged 70 years and older leads to the best prediction of dementia, regardless of subjective complaints.
背景/目的：在人群研究中，不同的轻度认知障碍（MCI）定义被用于预测后期的痴呆症。本研究比较了不同MCI定义对痴呆症的预测价值，并研究了年龄对预测价值的影响。
本研究是正在进行的关于认知老化决定因素的纵向研究——马斯特里赫特老化研究的一部分。
当考虑多个认知领域且不考虑主观主诉时，MCI对痴呆症的预测效果最佳（敏感性：0.66，特异性：0.78）。年龄对MCI预测痴呆症的敏感性有很大影响（60 - 70岁：敏感性 = 0.56；70 - 85岁：敏感性 = 0.70）。
纳入多个认知领域以及70岁及以上的参与者可实现对痴呆症的最佳预测，无论有无主观主诉。
