Han Bin, Zeng Ziqian, Wen Ying, Chen Chu, Cheng Daomei, Li Yachao, Huang Ning, Ruan Jia, Zhao Dan, Xue Qingping
Experimental Teaching Center of Public Health, School of Public Health, Chengdu Medical College, Chengdu, Sichuan, China.
Department of Epidemiology and Health Statistics, School of Public Health, Chengdu Medical College, Chengdu, Sichuan, 610500, China.
Arch Public Health. 2025 Jun 13;83(1):150. doi: 10.1186/s13690-025-01624-1.
Our study assesses the association between cumulative handgrip strength and longitudinal changes in cognitive function and daily functioning.
Two comparative cohort studies were used, including the English Longitudinal Study of Ageing (ELSA) and the Survey of Health, Ageing and Retirement in Europe (SHARE). Cumulative handgrip strength was calculated using three repeated measurements of handgrip strength. Linear mixed regression models evaluated the association between cumulative handgrip strength and longitudinal changes in cognitive function and daily functioning. Cox regression models were performed to determine the association between cumulative handgrip strength and the risk of cognitive and functional impairment.
Individuals with lower levels of cumulative handgrip strength had lower global cognition (β: -0.244; 95% CI: -0.317, -0.170 for ELSA and -0.359; -0.406, -0.311 for SHARE) and experienced a faster decline in cognitive function over time (-0.025; -0.037, -0.013 for ELSA, and -0.019; -0.026, -0.013 in SHARE). We found lower levels of cumulative handgrip strength were associated with lower daily functioning (β: 0.267; 95% CI: 0.161, 0.374 for ELSA and 0.153; 0.079, 0.227 for SHARE), and a faster decline in daily functioning over time (0.105; 0.081, 0.129 for ELSA and 0.217; 0.195, 0.238 for SHARE). Furthermore, lower levels of cumulative handgrip strength were related to a higher risk of cognitive and functional impairment.
Our study suggested that lower levels of cumulative handgrip strength was related to an accelerated decline in cognitive function and daily functioning. Persistently strengthening muscle strength should be emphasized in preventing neurodegenerative disorders and disabilities.
我们的研究评估了累积握力与认知功能和日常功能的纵向变化之间的关联。
使用了两项比较队列研究，包括英国老龄化纵向研究（ELSA）和欧洲健康、老龄化与退休调查（SHARE）。累积握力通过三次重复的握力测量计算得出。线性混合回归模型评估了累积握力与认知功能和日常功能纵向变化之间的关联。进行Cox回归模型以确定累积握力与认知和功能障碍风险之间的关联。
累积握力水平较低的个体具有较低的整体认知能力（β：-0.244；95%置信区间：ELSA为-0.317，-0.170；SHARE为-0.359，-0.406，-0.311），并且随着时间的推移认知功能下降更快（ELSA为-0.025，-0.037，-0.013；SHARE为-0.019，-0.026，-0.013）。我们发现累积握力水平较低与较低的日常功能相关（β：0.267；95%置信区间：ELSA为0.161，0.374；SHARE为0.153，0.079，0.227），并且随着时间的推移日常功能下降更快（ELSA为0.105，0.081，0.129；SHARE为0.217，0.195，0.238）。此外，累积握力水平较低与认知和功能障碍的较高风险相关。
我们的研究表明，累积握力水平较低与认知功能和日常功能的加速下降有关。在预防神经退行性疾病和残疾方面应强调持续增强肌肉力量。
