Dong Jie, Kislinger Thomas, Jurisica Igor, Wigle Dennis A
Division of General Thoracic Surgery, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, MN 55905, USA.
Cancer Biol Ther. 2009 Feb;8(4):312-8. doi: 10.4161/cbt.8.4.7522. Epub 2009 Feb 1.
High-throughput genomic data for both lung development and lung cancer continue to accumulate. Significant molecular intersection between these two processes has been hypothesized due to overlap in phenotypes and genomic variation. Examining the network biology of both cancer and development of the lung may shed functional light on the individual signaling modules involved. Stem cell biology may explain a portion of this network intersection and consequently studying lung organogenesis may have relevance for understanding lung cancer. This review summarizes our understanding of the potential overlapping mechanisms involved in lung development and lung tumorigenesis.
关于肺发育和肺癌的高通量基因组数据持续积累。由于表型和基因组变异的重叠，人们推测这两个过程之间存在显著的分子交叉。研究肺癌和肺发育的网络生物学可能会揭示其中涉及的各个信号模块的功能。干细胞生物学可能解释了这一网络交叉的一部分，因此研究肺器官发生可能与理解肺癌有关。这篇综述总结了我们对肺发育和肺肿瘤发生中潜在重叠机制的理解。
