Suyama Shigetomo, Takano Eisuke, Iwasaki Yusaku, Nakata Masanori, Yada Toshihiko
Department of Physiology, Division of Integrative Physiology, Jichi Medical University, School of Medicine.
Nihon Rinsho. 2009 Feb;67(2):277-86.
The brain controls feeding via two components; homeostatic and accessory regulation. Homeostatic regulation is executed by the hypothalamic centers. Accessory regulation occurs in response to environmental conditions and stimuli such as memory, stress, emotion, reward and hedonic feeling, which are operated by the limbic system, particularly the hippocampus and amygdala. Nutrients and visceral hormones, representing peripheral metabolic states, regulate activity of these brain areas, which is performed by direct action after entering through blood-brain area and by sending information via the vagus nerve and brain stem. We here review how the hippocampus and amygdala as well as gut, brain stem and hypothalamus function and interact with each other to achieve integrative regulation of feeding.
稳态调节和辅助调节。稳态调节由下丘脑中枢执行。辅助调节是对环境条件和刺激（如记忆、压力、情绪、奖励和享乐感觉）做出的反应，这些由边缘系统，特别是海马体和杏仁核控制。代表外周代谢状态的营养物质和内脏激素调节这些脑区的活动，这通过进入血脑屏障后的直接作用以及通过迷走神经和脑干发送信息来实现。我们在此综述海马体、杏仁核以及肠道、脑干和下丘脑如何发挥功能并相互作用，以实现对进食的综合调节。
