Katabami Takuyuki, Tanaka Yasushi
Division of Metabolism and Endocrinology, Department of Medicine, St. Marianna University of Medicine.
Nihon Rinsho. 2009 Feb;67(2):307-12.
Obesity is primarily defined by excess of body fat. Skinfold test, bioelectrical impedance analysis, and dual energy X-ray absorptiometry are useful clinicial tests for determining body fat volume or rate. It has shown that visceral fat or abdominal obesity strongly correlated with insulin resistance and cardiovascular diseases. So, visceral fat area at the level of umbilicus by CT is usually assessed as a risk factor of lifestyle-related disease or atherosclerosis. In obese subject, excess of fat accumulation is observed in muscle and liver, which are associated with insulin resistance. Thus, intrahepatic and intramyocellular lipids recently have been measured by 1H-MRS method as the useful markers of insulin resistance.
肥胖主要由体内脂肪过多来定义。皮褶厚度测试、生物电阻抗分析和双能X线吸收法是用于确定身体脂肪量或比例的有用临床检测方法。研究表明,内脏脂肪或腹型肥胖与胰岛素抵抗和心血管疾病密切相关。因此,通过CT测量脐水平的内脏脂肪面积通常被评估为生活方式相关疾病或动脉粥样硬化的一个危险因素。在肥胖个体中,肌肉和肝脏中会出现过多的脂肪堆积,这与胰岛素抵抗有关。因此,肝内和肌细胞内脂质最近已通过1H-MRS方法进行测量,作为胰岛素抵抗的有用标志物。