Razeghi E, Hadadi A, Khashayar P, Pourmand G
Nephrology, Urology Research Center, Sina Hospital, Medical Sciences, University of Tehran, Iran.
Clin Nephrol. 2009 Feb;71(2):214-6. doi: 10.5414/cnp71214.
Kaposi's sarcoma (KS) is one of the most common post transplant malignancies. A variety of factors appears to contribute to the development of KS including genetic factors, sex hormones, immunosuppression and oncogene viruses. We present 3 cases with concurrent KS and cytomegalovirus (CMV) infection in the first year after kidney transplantation. The suspicion on KS due to the skin lesions was confirmed by biopsy. The diagnosis of CMV infection was made by detecting pp65 antigen in blood. The KS lesions were limited to the skin in 2 patients, while skin and gastrointestinal tract were involved in 1 patient. Many factors are reported to be involved in KS development, but the simultaneous occurrence of KS and CMV infection in our three cases suggested CMV as an inducing factor for KS.
卡波西肉瘤（KS）是最常见的移植后恶性肿瘤之一。多种因素似乎都与KS的发生有关，包括遗传因素、性激素、免疫抑制和致癌基因病毒。我们报告了3例肾移植后第一年同时发生KS和巨细胞病毒（CMV）感染的病例。皮肤病变引发了对KS的怀疑，活检证实了这一诊断。通过检测血液中的pp65抗原做出CMV感染的诊断。2例患者的KS病变仅限于皮肤，而1例患者的皮肤和胃肠道均受累。据报道，许多因素都与KS的发生有关，但我们这3例病例中KS和CMV感染同时出现表明CMV是KS的诱发因素。
