在产前诊断可用前后，患库利贫血的家系的生殖行为。
Reproductive behaviour of families segregating for Cooley's anaemia before and after the availability of prenatal diagnosis.
作者信息
Gamberini M R, Lucci M, Vullo C, Anderson B, Canella R, Barrai I
机构信息
Institute of Zoology, University of Ferrara, Italy.
出版信息
J Med Genet. 1991 Aug;28(8):523-9. doi: 10.1136/jmg.28.8.523.
The reproductive behaviour of couples with heterozygous beta thalassaemia, with at least one affected child, was investigated for the period 1955 to 1984 and was compared to the behaviour of control couples matched for age, age at marriage, and presence of at least one child. The comparisons were made as a function of knowledge of the risk and availability of prenatal diagnosis and abortion. It was found that the couples segregating for Cooley's anaemia, before knowledge of the risk, had a higher reproductive rate than that of control couples. Knowledge of the genetic risk had a different effect on reproductive behaviour in the 1950s from that in later years. The difference was attributed both to the influence of cultural factors and to technical, therapeutic, and diagnostic advances.
对1955年至1984年期间至少育有一名患病子女的杂合子β地中海贫血夫妇的生殖行为进行了调查，并与年龄、结婚年龄和至少育有一名子女相匹配的对照夫妇的行为进行了比较。比较是根据风险知晓情况、产前诊断和堕胎的可获得性进行的。结果发现，在知晓风险之前，患有库利贫血的夫妇的生殖率高于对照夫妇。20世纪50年代与之后几年，遗传风险知晓情况对生殖行为的影响有所不同。这种差异既归因于文化因素的影响，也归因于技术、治疗和诊断方面的进步。
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