霍尔木兹甘省地中海贫血患儿家庭的生育行为
The Reproductive Behavior of Families with Thalassemic Children in Hormozgan.
作者信息
Safari Moradabadi Ali, Alavi Azin, Eqbal Eftekhaari Tasnim, Dadipoor Sakineh
机构信息
Health Promotion Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Hormozgan Fertility and Infertility Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
出版信息
J Reprod Infertil. 2015 Jul-Sep;16(3):167-70.
BACKGROUND
Thalassemic disorders are the most prevalent monogenic hereditary diseases around the world caused by decreased and altered synthesis or agenesis in one or more globin chains. Families who have a child with thalassemia major face a myriad of significant problems. Hormozgan province ranks second with thalassemic patients in Iran. Therefore, current research is aimed to analyze the reproductive behavior of such families in the southern province of Iran.
METHODS
In this descriptive study 190 mothers of patients suffering from thalassemia major were included. The reproductive behavior of mothers was investigated by a questionnaire regarding the number of thalassemic infants born after their first child with thalassemia major.
RESULTS
About 23% of these mothers had more than 1 child with major thalassemia. The findings showed that the reasons for conception among these mothers were to have a healthy child (64.2%) and to have a boy (20%). In about 92.6% of mothers CVS test was not performed.
CONCLUSION
This study showed that awaring mothers and families regarding the prevention of birth of afflicted infants and provision of accessible diagnostic facilities can reduce the number of children with thalassemia major.
背景
地中海贫血症是全球最常见的单基因遗传性疾病，由一条或多条珠蛋白链合成减少、改变或缺失引起。有重型地中海贫血患儿的家庭面临着众多重大问题。霍尔木兹甘省的地中海贫血患者数量在伊朗排名第二。因此，当前研究旨在分析伊朗南部此类家庭的生育行为。
方法
在这项描述性研究中，纳入了190名重型地中海贫血症患儿的母亲。通过一份关于她们第一个重型地中海贫血症患儿出生后所生重型地中海贫血症患儿数量的问卷，对母亲们的生育行为进行了调查。
结果
这些母亲中约23%有不止一个重型地中海贫血症患儿。研究结果表明，这些母亲怀孕的原因是想要一个健康的孩子（64.2%）以及想要一个男孩（20%）。约92.6%的母亲未进行绒毛取样检查。
结论
本研究表明，提高母亲和家庭对预防患病婴儿出生的认识，并提供可及的诊断设施，可减少重型地中海贫血症患儿的数量。
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