Modell B, Ward R H, Fairweather D V
Br Med J. 1980 Jun 7;280(6228):1347-50. doi: 10.1136/bmj.280.6228.1347.
Families who were at risk of producing a child with thalassaemia major were studied to determine the sequential effects on their reproductive behaviour of knowing the risk and, subsequently, of knowing that antenatal diagnosis was available. Knowing the risk caused them virtually to stop reproduction and to seek termination of 70% of pregnancies, most of which were accidental. The introduction of antenatal diagnosis in 1975 permitted the resumption of nearly normal reproduction by at-risk families, with fewer than 30% of pregnancies being terminated for thalassaemia major. All couples at risk for thalassaemia major should be detected and counselled before they produce an affected child; responsibility for either choosing or refusing antenatal diagnosis should be theirs alone.
对有生出重型地中海贫血患儿风险的家庭进行了研究，以确定知晓风险以及随后知晓可进行产前诊断对其生育行为的一系列影响。知晓风险实际上导致他们停止生育，并寻求终止70%的妊娠，其中大多数是意外怀孕。1975年引入产前诊断后，有风险的家庭得以恢复几乎正常的生育，因重型地中海贫血而终止的妊娠不到30%。所有有重型地中海贫血风险的夫妇都应在生出患病孩子之前被检测出来并接受咨询；选择或拒绝产前诊断的责任应完全由他们自己承担。
