Maggi Paolo, Bellacosa Chiara, Grattagliano Vito, Pastore Giuseppe, Lapadula Giovanni
Institute of Infectious Diseases, University of Bari, Bari, Italy.
HIV Clin Trials. 2008 Nov-Dec;9(6):428-33. doi: 10.1310/hct0906-428.
The aim of our study was to investigate the morphologic and functional characteristics of microcirculation in HIV-positive patients. Microcirculation was investigated by means of capillaroscopy and laser Doppler fluxometry (LDF). The results were compared with those obtained from healthy subjects and patients affected by sclerodermia.
We evaluated 140 subjects: 69 HIV-positive, 48 sclerodermic, and 23 healthy individuals. The groups were compared for resting flow (RF), mean flow during cold test, mean flow during the recovery, postocclusive reaction, and time of recovery after reactive hyperaemia.
RF (p = .0035), flow during the cold test (p = .008), recovery (p = .03), and postocclusive reaction (p = .007) results were higher in HIV-1 positive patients with respect to the other two groups. Recovery after postocclusive reaction in HIV-positive patients was longer than in healthy individuals. Time from diagnosis and a pathologic electromyography were significantly related to a vasospasm reduction induced by the cold test (p = .022). The recovery was also influenced by the time from disease diagnosis (p = .0016).
HIV patients seem to have an altered microcirculation regulation, with increased perfusion of the capillary territory. This could be related to the length of period of infection and a coexisting neuropathy.
我们研究的目的是调查HIV阳性患者微循环的形态学和功能特征。通过毛细血管显微镜检查和激光多普勒血流仪（LDF）对微循环进行研究。将结果与健康受试者和硬皮病患者的结果进行比较。
我们评估了140名受试者：69名HIV阳性、48名硬皮病患者和23名健康个体。比较了各组的静息血流（RF）、冷试验期间的平均血流、恢复期间的平均血流、闭塞后反应以及反应性充血后的恢复时间。
HIV-1阳性患者的RF（p = .0035）、冷试验期间的血流（p = .008）、恢复（p = .03）和闭塞后反应（p = .007）结果高于其他两组。HIV阳性患者闭塞后反应后的恢复时间比健康个体长。诊断时间和病理性肌电图与冷试验引起的血管痉挛减轻显著相关（p = .022）。恢复也受疾病诊断时间的影响（p = .0016）。
HIV患者似乎存在微循环调节改变，毛细血管区域灌注增加。这可能与感染时间长短和并存的神经病变有关。
