Ergen F Bilge, Akata Deniz, Hayran Mutlu, Harmanci Ozgur, Arslan Serap, Basaran Ceyla, Hussain Hero K
Department of Radiology, Hacettepe University, Faculty of Medicine, Ankara, Turkey.
J Comput Assist Tomogr. 2008 Nov-Dec;32(6):848-54. doi: 10.1097/RCT.0b013e31815b63ff.
To identify and evaluate quantitative parameters of colonic inflammation in patients with inflammatory bowel disease (IBD) compared with conventional colonoscopy (CC).
Retrospectively, 37 consecutive patients who underwent MR colonography (MRC) from March 03- April 06 were included in this study. Patients with suspected and known IBD (n = 22) constituted the study group (SG) and those evaluated for colonic polyps (n = 15) constituted the control group. All patients in the SG underwent CC. Magnetic resonance colonography was performed using a gadolinium-enhanced coronal 3-dimensional gradient-echo sequence. The colon was divided into segments, and each segment was evaluated in consensus by 2 abdominal radiologists blinded to the CC findings. Readers assessed the bowel wall thickness index, the signal intensity index of colonic wall, and the caliber of vasa recta in all segments. Indices calculated from colonoscopically diseased and nondiseased segments were compared using Mann-Whitney U test. Receiver operator characteristic analysis was used to determine the use of these indices in predicting the presence of colonic inflammation.
There were 60 colonoscopically diseased and 33 nondiseased segments in the SG. For all 3 MR indices, there was a significant difference (P < 0.05) in these indices between diseased and nondiseased segments. Bowel wall thickness index, signal intensity index, and vasa recta values of 0.074, 118% and 0.25 mm, respectively, had 63% sensitivity and 80% specificity for predicting colonic inflammation.
Inflammatory changes in the colon can be demonstrated on MRC in patients with IBD with moderate sensitivity and high specificity using quantitative parameters.
与传统结肠镜检查（CC）相比，识别并评估炎症性肠病（IBD）患者结肠炎症的定量参数。
本研究回顾性纳入了2003年3月至2006年4月期间连续接受磁共振结肠成像（MRC）的37例患者。疑似和已知IBD患者（n = 22）组成研究组（SG），接受结肠息肉评估的患者（n = 15）组成对照组。SG中的所有患者均接受了CC。磁共振结肠成像采用钆增强冠状位三维梯度回波序列进行。将结肠分为多个节段，由2名对CC结果不知情的腹部放射科医生共同对每个节段进行评估。阅片者评估所有节段的肠壁厚度指数、结肠壁信号强度指数和直小血管口径。使用Mann-Whitney U检验比较从结肠镜检查的病变节段和非病变节段计算得出的指数。采用受试者操作特征分析来确定这些指数在预测结肠炎症存在方面的用途。
SG中有60个结肠镜检查病变节段和33个非病变节段。对于所有3个磁共振指数，病变节段和非病变节段之间这些指数存在显著差异（P < 0.05）。肠壁厚度指数、信号强度指数和直小血管值分别为0.074、118%和0.25 mm，对预测结肠炎症的敏感性为63%，特异性为80%。
IBD患者结肠的炎症性改变可通过MRC使用定量参数以中等敏感性和高特异性显示出来。
