久坐不动的绝经后女性运动及健身无反应量
Volume of exercise and fitness nonresponse in sedentary, postmenopausal women.
作者信息
Sisson Susan B, Katzmarzyk Peter T, Earnest Conrad P, Bouchard Claude, Blair Steven N, Church Timothy S
机构信息
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
出版信息
Med Sci Sports Exerc. 2009 Mar;41(3):539-45. doi: 10.1249/MSS.0b013e3181896c4e.
UNLABELLED
There is a wide individual heterogeneity in the maximal aerobic fitness (V x O 2max) response to exercise training.
PURPOSE
To examine predictors of V x O 2max nonresponse after aerobic exercise training in postmenopausal women.
METHODS
The Dose Response to Exercise in Women (DREW) study was a randomized, controlled trial examining the effects of incremental training doses on sedentary postmenopausal women (45-75 yr). Participants were randomized to one of three exercise treatment groups (4, 8, or 12 kcal x kg(-1) x wk(-1)) for 6 months. Participants exercised 3-4 d x wk(-1) at 50% V x O 2max. Predictors of baseline V x O 2max were determined by ANOVA. We used a logistic regression analyses with categorical (ethnicity and treatment group) and standardized continuous variables (age, body mass index [BMI], and baseline V x O 2max) to determine predictors of nonresponse (Delta <or= 0 L x min(-1)). Our analysis included 310 women because the control group was excluded.
RESULTS
A total of 44.9%, 23.8%, and 19.3% of the 4-, the 8-, and the 12-kcal x kg(-1) x wk(-1) treatment groups (P < 0.0001), respectively, were nonresponders. Maximal effort, BMI, age, and race significantly predicted baseline V x O 2max. Treatment group (8 and 12 kcal x kg(-1) x wk(-1) vs 4 kcal x kg(-1) x wk(-1); P = 0.0003), baseline V x O 2max (P < 0.0001), and age (P < 0.05) were significant predictors of nonresponse. Odds ratios and 95% confidence intervals were 2.13 (1.53-2.95) for baseline V x O 2max; 1.35 (1.00-1.83) for age; 0.45 (0.24-0.85) for the 8- versus the 4-kcal x kg(-1) x wk(-1) group; and 0.27 (0.13-0.53) for the 12- versus the 4-kcal x kg(-1) x wk(-1) group.
CONCLUSION
Women that were younger, less fit, or exercised more during the DREW trial had greater odds of improving their fitness with training. The most important finding of this study was that greater volumes of exercise were associated with a lower probability of being a nonresponder.
未标注
最大有氧适能（V̇O₂max）对运动训练的反应存在广泛的个体异质性。
目的
研究绝经后女性有氧运动训练后V̇O₂max无反应的预测因素。
方法
女性运动剂量反应（DREW）研究是一项随机对照试验，研究递增训练剂量对久坐的绝经后女性（45 - 75岁）的影响。参与者被随机分配到三个运动治疗组之一（4、8或12千卡·千克⁻¹·周⁻¹），为期6个月。参与者每周3 - 4天以50% V̇O₂max进行运动。通过方差分析确定基线V̇O₂max的预测因素。我们使用逻辑回归分析，纳入分类变量（种族和治疗组）以及标准化连续变量（年龄、体重指数[BMI]和基线V̇O₂max）来确定无反应（Δ≤0升·分钟⁻¹）的预测因素。由于排除了对照组，我们的分析纳入了310名女性。
结果
4千卡·千克⁻¹·周⁻¹、8千卡·千克⁻¹·周⁻¹和12千卡·千克⁻¹·周⁻¹治疗组分别有44.9%、23.8%和19.3%的参与者无反应（P < 0.0001）。最大努力程度、BMI、年龄和种族显著预测基线V̇O₂max。治疗组（8和12千卡·千克⁻¹·周⁻¹对比4千卡·千克⁻¹·周⁻¹；P = 0.0003）、基线V̇O₂max（P < 0.0001）和年龄（P < 0.05）是无反应的显著预测因素。基线V̇O₂max的优势比和95%置信区间为2.13（1.53 - 2.95）；年龄为1.35（1.00 - 1.83）；8千卡·千克⁻¹·周⁻¹组对比4千卡·千克⁻¹·周⁻¹组为0.45（0.24 - 0.85）；12千卡·千克⁻¹·周⁻¹组对比4千卡·千克⁻¹·周⁻¹组为0.27（0.13 - 0.53）。
结论
在DREW试验中，年龄较小、身体适能较低或运动较多的女性通过训练提高适能的几率更大。本研究最重要的发现是，运动量越大，成为无反应者的概率越低。
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