Chen Yue, Rennie Donna, Cormier Yvon, Dosman James A
Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Pediatr Pulmonol. 2009 Mar;44(3):216-21. doi: 10.1002/ppul.20854.
In adults abdominal obesity is related to lung dysfunction and waist circumference (WC) predicts pulmonary function. It is not known how WC affects pulmonary function in children. A cross-sectional study of 718 children 6-17 years of age was conducted in a rural community to determine the predictability of WC for pulmonary function in children. Height, weight, WC, and pulmonary function were measured. Multivariate analysis was conducted. WC was positively associated with FVC and FEV(1) and was more strongly associated with FVC than with FEV(1). Increase in WC significantly predicted a reduction in FEV(1)/FVC. After adjustment for sex, age, and height, an increase of 1 cm for WC was associated with an increase of 7 ml of FVC and 4 ml of FEV(1), and with an increase of 4 ml of FVC and 2 ml of FEV(1) with an additional adjustment for weight. Height and weight were not significantly associated with FEV(1)/FVC. WC but not body mass index predicted a decline of FEV(1)/FVC. WC had a larger impact on FVC than FEV(1). WC, but not BMI, was negatively associated with FEV(1)/FVC in children.
在成年人中，腹部肥胖与肺功能障碍有关，腰围（WC）可预测肺功能。目前尚不清楚WC如何影响儿童的肺功能。在一个农村社区对718名6至17岁的儿童进行了一项横断面研究，以确定WC对儿童肺功能的预测能力。测量了身高、体重、WC和肺功能。进行了多变量分析。WC与用力肺活量（FVC）和第一秒用力呼气容积（FEV₁）呈正相关，且与FVC的相关性强于与FEV₁的相关性。WC增加显著预测FEV₁/FVC降低。在调整性别、年龄和身高后，WC每增加1厘米，FVC增加7毫升，FEV₁增加4毫升；在进一步调整体重后，FVC增加4毫升，FEV₁增加2毫升。身高和体重与FEV₁/FVC无显著相关性。WC而非体重指数可预测FEV₁/FVC下降。WC对FVC的影响大于对FEV₁的影响。在儿童中，与FEV₁/FVC呈负相关的是WC而非BMI。
