Kagu M B, Khalil M I A, Ahmed S G
Department of Haematology, University of Maiduguri Teaching Hospita,l PMB.1414, Maiduguri, Borno State, Nigeria.
Afr J Med Med Sci. 2007 Jun;36(2):125-8.
Several observations have been made suggesting that excess iron is harmful to patients with HIV/AIDS disease. Bone marrow macrophage iron stores of 30 anaemic HIV infected patients (median age 32.7 years) and 20 anaemic AIDS-associated Kaposi's sarcoma patients (median age 37 years) were studied at the haematology department of the University of Maiduguri Teaching Hospital. Macrophage iron stores were assessed as either normal, decreased or increased by using grades ranging from 0 to 6. Marrow iron stores was increased in 16 (80%) of the patients with Kaposi's sarcoma and normal in 4 (20%) patients. Three of the 4 patients with normal iron stores were females of reproductive age. Regression analysis of iron status and opportunistic infection showed a positive correlation (p-value=0.001). Of the 30 patients with HIV infection, 22 (73.3%) had normal iron stores and 8 (26.7%) had decreased iron stores. All the 8 (26.7%) patients with no stainable iron in the marrow were females of reproductive age group. Iron deficiency anaemia can complicate anaemia of HIV infected patients. In view of the documented risk associated with iron supplementation in anaemic patients with HIV/AIDS disease, little caution should be exercise as regards the use of haematinics and/or blood tonics in anaemic HIV-infected or AIDS-associated Kaposi's sarcoma patients. The fact that noninvasive evaluation for iron deficiency is compromised in many individuals due to the presence of chronic inflammatory process and/or malignancy, bone marrow evaluation for iron stores still remains an important tool often underutilized by many clinicians attending to patients living with HIV/AIDS.
已有多项观察结果表明，铁过量对艾滋病毒/艾滋病患者有害。在迈杜古里大学教学医院血液科，对30名贫血的艾滋病毒感染患者（中位年龄32.7岁）和20名贫血的艾滋病相关卡波西肉瘤患者（中位年龄37岁）的骨髓巨噬细胞铁储存情况进行了研究。通过使用0至6级来评估巨噬细胞铁储存，分为正常、减少或增加。卡波西肉瘤患者中16例（80%）骨髓铁储存增加，4例（20%）正常。4例铁储存正常的患者中有3例为育龄女性。铁状态与机会性感染的回归分析显示呈正相关（p值 = 0.001）。在30名艾滋病毒感染患者中，22例（73.3%）铁储存正常，8例（26.7%）铁储存减少。骨髓中无可染色铁的所有8例（26.7%）患者均为育龄女性。缺铁性贫血会使艾滋病毒感染患者的贫血情况复杂化。鉴于有记录表明艾滋病毒/艾滋病贫血患者补充铁剂存在风险，在艾滋病毒感染或艾滋病相关卡波西肉瘤贫血患者中使用补血剂和/或补血药时应谨慎。由于存在慢性炎症过程和/或恶性肿瘤，许多个体的缺铁非侵入性评估受到影响，对于艾滋病毒/艾滋病患者的许多临床医生而言，骨髓铁储存评估仍是一项常未得到充分利用的重要工具。
