Nordborg Anna, Hilder Emily F
Pfizer Analytical Research Centre, Australian Centre for Research on Separation Science, School of Chemistry, University of Tasmania, Private Bag 75, Hobart, 7001, Tasmania, Australia.
Anal Bioanal Chem. 2009 May;394(1):71-84. doi: 10.1007/s00216-009-2636-9. Epub 2009 Feb 11.
The use of polymeric materials in ion-exchange chromatography applications is advantageous because of their typically high mechanical stability and tolerance of a wide range of pH conditions. The possibility of using polymeric monoliths in ion-exchange chromatography is therefore obvious and many of the same strategies developed for polymeric particles have been adapted for use with polymeric monoliths. In this review different strategies for the synthesis of polymeric monoliths with ion-exchange functionality are discussed. The incorporation of ion-exchange functionality by co-polymerization is included, as also are different post-polymerization alterations to the monolith surface such as grafting. The formulations and strategies presented include materials intended for use in analytical separations in ion-exchange chromatography, sample pre-treatment or enrichment applications, and materials for capillary electrochromatography. Finally, examples of the use of polymeric monoliths in ion-exchange chromatography applications are included with examples published in the years 2003 to 2008.
在离子交换色谱应用中使用聚合物材料具有优势，因为它们通常具有较高的机械稳定性，并且能耐受广泛的pH条件。因此，在离子交换色谱中使用聚合物整体柱的可能性显而易见，并且许多为聚合物颗粒开发的相同策略已被改编用于聚合物整体柱。在这篇综述中，讨论了合成具有离子交换功能的聚合物整体柱的不同策略。包括通过共聚引入离子交换功能，以及对整体柱表面进行的不同后聚合改性，如接枝。所介绍的配方和策略包括用于离子交换色谱分析分离、样品预处理或富集应用的材料，以及用于毛细管电色谱的材料。最后，还包括了2003年至2008年发表的聚合物整体柱在离子交换色谱应用中的使用实例。
