Australian Center for Research on Separation Science, School of Chemistry, University of Tasmania, Hobart, Tasmania 7001, Australia.
Annu Rev Anal Chem (Palo Alto Calif). 2011;4:197-226. doi: 10.1146/annurev-anchem-061010-113929.
Monolithic media are continuing to increase in popularity in chromatographic applications, and the ongoing use of commercially available materials in ion chromatography (IC) has made monoliths a viable alternative to packed-bed columns for routine use. We discuss different strategies for the synthesis of polymeric and silica monoliths with ion-exchange functionality, such as direct incorporation of ion-exchange functionality during monolith preparation and different postpolymerization alterations such as grafting and coating. The formulations and strategies presented are focused on materials intended for use in IC. We also discuss strategies for materials characterization, with emphasis on nondestructive techniques for the characterization of monolith surface functionality, especially those with applicability to in situ analysis. Finally, we describe selected IC applications of polymeric and silica monoliths published from 2008 to 2010.
整体式介质在色谱应用中继续受到欢迎，商业上可用的材料在离子色谱（IC）中的持续使用使得整体式介质成为填充床柱的常规替代品。我们讨论了用于合成具有离子交换功能的聚合物和硅胶整体式介质的不同策略，例如在整体式介质制备过程中直接掺入离子交换功能，以及不同的聚合后修饰，如接枝和涂覆。所提出的配方和策略集中于用于 IC 的材料。我们还讨论了材料表征策略，重点是用于整体式介质表面功能表征的无损技术，特别是那些适用于原位分析的技术。最后，我们描述了 2008 年至 2010 年发表的聚合物和硅胶整体式介质在 IC 中的一些应用。
