慢性疼痛对α2-肾上腺素能受体激动剂赛拉嗪在绵羊体内镇痛效果的影响。

The influence of chronic pain on the analgesic effects of the alpha 2-adrenoceptor agonist, xylazine, in sheep.

作者信息

Ley S, Waterman A, Livingston A

机构信息

Department of Pharmacology, University of Bristol, UK.

出版信息

J Vet Pharmacol Ther. 1991 Jun;14(2):141-4. doi: 10.1111/j.1365-2885.1991.tb00815.x.

DOI:10.1111/j.1365-2885.1991.tb00815.x

PMID:1920601

Abstract

A comparison of the analgesic potency of the alpha 2-adrenoceptor agonist, xylazine, in control healthy sheep and sheep suffering chronic pain from footrot, indicated that the analgesic effectiveness of xylazine was significantly reduced in the animals experiencing chronic pain. This was measured by recording the threshold to a mechanically applied pressure stimulus. Furthermore, when the condition was apparently resolved, by conventional treatment over a period of 2 to 3 weeks, the decreased analgesic effectiveness of the alpha 2-agonist was still apparent although the animals were clinically cured of the footrot.

摘要

对α2-肾上腺素能受体激动剂赛拉嗪在健康对照绵羊和患有腐蹄病慢性疼痛的绵羊中的镇痛效力进行比较，结果表明，在经历慢性疼痛的动物中，赛拉嗪的镇痛效果显著降低。这是通过记录对机械施加压力刺激的阈值来测量的。此外，当通过2至3周的常规治疗使病情明显缓解时，尽管动物的腐蹄病在临床上已治愈，但α2-激动剂降低的镇痛效果仍然明显。