莫洛尼鼠白血病病毒在gag-pol连接区发生突变的回复突变体分析。
Analysis of Moloney murine leukemia virus revertants mutated at the gag-pol junction.
作者信息
Odawara T, Yoshikura H, Ohshima M, Tanaka T, Jones D S, Nemoto F, Kuchino Y, Iwamoto A
机构信息
Department of Bacteriology, Faculty of Medicine, University of Tokyo, Japan.
出版信息
J Virol. 1991 Nov;65(11):6376-9. doi: 10.1128/JVI.65.11.6376-6379.1991.
Among Moloney murine leukemia viruses (Mo-MuLVs) having stop codons other than UAG at the gag-pol junction, Mo-MuLV with UAA, but not with UGA, had a replication disadvantage. Mo-MuLV with a glutamine codon (CAG) at the junction did not replicate. A revertant of this virus consisted of the original virus and a virus with a deletion of the pol region. Protease and Pr65gag encoded by their respective genomes complemented each other.
在莫洛尼鼠白血病病毒（Mo-MuLVs）中，在gag-pol连接区具有除UAG以外的终止密码子的病毒中，带有UAA而非UGA的Mo-MuLV具有复制劣势。在连接区带有谷氨酰胺密码子（CAG）的Mo-MuLV无法复制。该病毒的一个回复突变体由原始病毒和一个缺失pol区域的病毒组成。它们各自基因组编码的蛋白酶和Pr65gag相互互补。
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