Kablik Jeffrey, Monheit Gary D, Yu LiPing, Chang Grace, Gershkovich Julia
Genzyme Corporation, Cambridge, Massachusetts 01701, USA.
Dermatol Surg. 2009 Feb;35 Suppl 1:302-12. doi: 10.1111/j.1524-4725.2008.01046.x.
Hyaluronic acid (HA) fillers are becoming the material of choice for use in cosmetic soft tissue and dermal correction. HA fillers appear to be similar, but their physical characteristics can be quite different. These differences have the potential to affect the ability of the physician to provide the patient with a natural and enduring result.
The objective of this article is to discuss the key physical properties and methods used in characterizing dermal fillers. These methods were then used to analyze several well-known commercially available fillers.
Analytical methods were employed to generate data on the properties of various fillers. The measured physical properties were concentration, gel-to-fluid ratio, HA gel concentration, degree of HA modification, percentage of cross-linking, swelling, modulus, and particle size.
The results demonstrated that commercial fillers exhibit a wide variety of properties.
Combining the objective factors that influence filler performance with clinical experience will provide the patient with the optimal product for achieving the best cosmetic result. A careful review of these gel characteristics is essential in determining filler selection, performance, and patient expectations.
透明质酸（HA）填充剂正成为用于美容软组织和真皮矫正的首选材料。HA填充剂看似相似，但其物理特性可能差异很大。这些差异有可能影响医生为患者提供自然持久效果的能力。
本文的目的是讨论用于表征真皮填充剂的关键物理特性和方法。然后使用这些方法分析几种知名的市售填充剂。
采用分析方法生成各种填充剂特性的数据。所测量的物理特性包括浓度、凝胶与流体比例、HA凝胶浓度、HA修饰程度、交联百分比、膨胀率、模量和粒径。
结果表明市售填充剂表现出各种各样的特性。
将影响填充剂性能的客观因素与临床经验相结合，将为患者提供实现最佳美容效果的最佳产品。仔细审查这些凝胶特性对于确定填充剂的选择、性能和患者期望至关重要。
