Segura Sandrine, Anthonioz Lise, Fuchez Fabien, Herbage Benjamin
Galderma R&D, Sophia Antipolis, France.
J Drugs Dermatol. 2012 Jan;11(1 Suppl):s5-8.
A new range of hyaluronic acid (HA) dermal fillers has been designed using Optimal Balance Technology™, which centers around three main parameters: the degree of cross-linking, the size of gel calibration and the HA concentration. The five different products in the range (HA E Touch, HA E Classic, HA E Lips, HA E Deep and HA E Volume) have the same concentration of HA (20 mg/mL) and various degrees of cross-linking and gel calibration, in order to have distinctive physical properties adapted to their specific indications. HA E Classic, HA E Deep, HA E Lips and HA E Volume are available in two different formulations either with or without lidocaine. The efficacy, safety and patient satisfaction of the HA E range in various indications have been assessed in several classical studies. In this study, the rheological measurements of HA E Deep being the firmest gel within the range. Addition of lidocaine did not change the rheological properties of the HA E fillers. HA E fillers have three different degrees of gel calibration, with HA E Touch, HA E Classic and HA E Lips having the same smallest gel calibration and HA E Volume having the largest gel calibration within the range. Injection of all HA E fillers was smooth, regular, and required low extrusion force when using the Ultra Thin Wall (UTW)needle provided for each product. In summary, the HA E fillers have distinctive physical properties in terms of gel firmness and gel calibration, which were designed to adapt to their specific indications.
采用优化平衡技术™设计了一系列新型透明质酸(HA)真皮填充剂,该技术围绕三个主要参数:交联度、凝胶校准尺寸和HA浓度。该系列中的五种不同产品(HA E Touch、HA E Classic、HA E Lips、HA E Deep和HA E Volume)具有相同的HA浓度(20 mg/mL)以及不同程度的交联和凝胶校准,以便具有适应其特定适应症的独特物理特性。HA E Classic、HA E Deep、HA E Lips和HA E Volume有两种不同配方,含或不含利多卡因。在多项经典研究中评估了HA E系列在各种适应症中的疗效、安全性和患者满意度。在本研究中,HA E Deep的流变学测量结果表明其为该系列中最硬的凝胶。添加利多卡因并未改变HA E填充剂的流变学特性。HA E填充剂有三种不同程度的凝胶校准,其中HA E Touch、HA E Classic和HA E Lips具有该系列中相同的最小凝胶校准,而HA E Volume具有最大的凝胶校准。使用为每种产品提供的超薄壁(UTW)针头注射所有HA E填充剂时都很顺畅、规律,且所需的挤出力较小。总之,HA E填充剂在凝胶硬度和凝胶校准方面具有独特的物理特性,这些特性旨在适应其特定适应症。