Stocks David, Sundaram Hema, Michaels Jason, Durrani Manzer J, Wortzman Mitchell S, Nelson Diane B
Intertek MSG, Redcar, United Kingdom.
J Drugs Dermatol. 2011 Sep;10(9):974-80.
Hyaluronic acid (HA) gels are commonly injected into the skin to lift rhytides and to improve facial appearance. The different processes used in their manufacture and formulation yield products with unique physical characteristics that play an important role in predicting their clinical performance.
The following rheologic evaluation was performed to objectively measure the physical characteristics of HA dermal filler products derived from similar bacterial sources and containing the same butanediol diglycidyl ether cross-linker, but formulated using different manufacturing techniques. The objective of this study was to evaluate the physical characteristics of two distinct families of HA products, thereby providing clinicians with a greater understanding of these products' attributes and the ability to optimize their use in the treatment of patients seeking facial rejuvenation.
The physical properties of commercially-available dermal fillers containing HA were evaluated using rheologic testing methods under clinically-relevant conditions. Additionally, light microscopy was used to assess the particulate nature of each product.
The gels tested demonstrated a broad range of elasticity, firmness and viscosity. Light microscopy confirmed the particulate nature of each product and revealed HA particles of varying size and distribution.
This rheologic evaluation demonstrates that differences exist among the HA products tested including gel elasticity, viscosity, and the range and distribution of gel particle sizes. Understanding the distinct physical characteristics of different HA dermal fillers and how these characteristics may predict their clinical behavior can assist clinicians in achieving the desired results in patients seeking facial rejuvenation.
透明质酸（HA）凝胶通常被注射到皮肤中以减轻皱纹并改善面部外观。其制造和配方中使用的不同工艺产生了具有独特物理特性的产品，这些特性在预测其临床性能方面起着重要作用。
进行以下流变学评估，以客观测量源自相似细菌来源、含有相同丁二醇二缩水甘油醚交联剂，但采用不同制造技术配制的HA真皮填充产品的物理特性。本研究的目的是评估两种不同系列HA产品的物理特性，从而使临床医生更好地了解这些产品的属性，并能够在治疗寻求面部年轻化的患者时优化其使用。
在临床相关条件下，使用流变学测试方法评估市售含HA真皮填充剂的物理性质。此外，使用光学显微镜评估每种产品的颗粒性质。
测试的凝胶表现出广泛的弹性、硬度和粘度。光学显微镜证实了每种产品的颗粒性质，并揭示了大小和分布各异的HA颗粒。
这项流变学评估表明，所测试的HA产品之间存在差异，包括凝胶弹性、粘度以及凝胶颗粒大小的范围和分布。了解不同HA真皮填充剂的独特物理特性以及这些特性如何预测其临床行为，有助于临床医生在寻求面部年轻化的患者中取得理想效果。
