Mitsui H, Shibagaki N, Kawamura T, Matsue H, Shimada S
Department of Dermatology, University of Yamanashi, Japan.
J Eur Acad Dermatol Venereol. 2009 Apr;23(4):394-401. doi: 10.1111/j.1468-3083.2008.03065.x.
Malignancy has been reported as a causative factor of cutaneous vasculitis, although only two retrospective epidemiological studies have analysed the association between Henoch-Schönlein purpura (HSP) and malignancy to date.
To analyse the association between adult HSP and malignancy.
We retrospectively reviewed the medical records of patients and found 103 cases of HSP over the past 20 years. Fifty-three cases (aged > or = 41 years) were categorized to two groups including 'with malignancy' or 'without malignancy', so that we could analyse the differences of clinical features between them. We also compared our study to previous reports.
Twenty-three cases out of 53 patients exhibited underlying malignant tumours. We focused on nine patients in which malignant tumours were thought to be strongly associated. Seven of nine patients exhibited new metastatic lesions or died due to underlying cancer within 1-32 months.
An association between HSP and malignant disease might have important diagnostic and pathophysiologic implications.
恶性肿瘤已被报道为皮肤血管炎的一个致病因素，尽管迄今为止仅有两项回顾性流行病学研究分析了过敏性紫癜（HSP）与恶性肿瘤之间的关联。
分析成人HSP与恶性肿瘤之间的关联。
我们回顾性查阅了患者的病历，发现在过去20年中有103例HSP病例。53例（年龄≥41岁）被分为“合并恶性肿瘤”或“未合并恶性肿瘤”两组，以便分析两组之间的临床特征差异。我们还将我们的研究与之前的报告进行了比较。
53例患者中有23例存在潜在恶性肿瘤。我们重点关注了9例被认为恶性肿瘤与之密切相关的患者。9例患者中有7例在1 - 32个月内出现了新的转移病灶或因潜在癌症死亡。
HSP与恶性疾病之间的关联可能具有重要的诊断和病理生理学意义。
