Arrhythmia Service, Division of Cardiology, University of Western Ontario, Canada.
J Cardiovasc Electrophysiol. 2009 Aug;20(8):931-4. doi: 10.1111/j.1540-8167.2008.01405.x. Epub 2009 Jan 16.
Pheochromocytoma may present with ECG abnormalities as one of the few clues to the diagnosis.
A 30-year-old woman presented with chest pain and a QTc of 525 ms. Four weeks later following a syncopal episode, her QTc was 660 ms. Short runs of monomorphic ventricular tachycardia were recorded. Investigations revealed an adrenal pheochromocytoma. Her QTc normalized after excision of the tumor. Comprehensive QT gene screening of KCNQ1, KCNH2, SCN5A, KCNE1, and KCNE2 was negative.
Pheochromocytoma may induce monomorphic VT and QT prolongation. The interaction of different catecholamines may have a compounding effect on cardiac repolarization.
嗜铬细胞瘤可能会出现心电图异常，这是诊断的少数线索之一。
一位 30 岁的女性因胸痛和 QTc 为 525ms 就诊。在晕厥发作后 4 周，她的 QTc 为 660ms。记录到短阵单形性室性心动过速。检查发现肾上腺嗜铬细胞瘤。肿瘤切除后 QTc 恢复正常。对 KCNQ1、KCNH2、SCN5A、KCNE1 和 KCNE2 的全面 QT 基因筛查均为阴性。
嗜铬细胞瘤可引起单形性 VT 和 QT 延长。不同儿茶酚胺的相互作用可能对心脏复极产生复合影响。
