Melo e Silva Fernanda, de Paula José Elias, Espindola Laila Salmen
Laboratório de Farmacognosia, Universidade de Brasília, Brasília, DF, Brazil.
Mycoses. 2009 Nov;52(6):511-7. doi: 10.1111/j.1439-0507.2008.01647.x. Epub 2009 Jan 9.
Therapeutic limitations, development of fungal drug resistance, drug-related toxicity, drug interactions and insufficient bioavailability of the currently available antifungal drugs have made the development of drugs necessary that would be able to treat the emerging fungal infections. The Cerrado is the second greater biome of Brazil and it was identified as one of the most distinguished biomes of South America, becoming an important source of innovative vegetal molecules to treat several conditions. Thus, the objective of this study was to evaluate the antifungal potential of Cerrado plants, mainly those used to treat infections and wounds. A total of 57 extracts were screened by the agar-well diffusion technique against Candida albicans and Trichophyton rubrum. The most promising extracts were tested in smaller concentrations and their minimal inhibitory concentrations (MIC) were determined by microdilution method. Results were analysed statistically by anova tests. Extracts of Kielmeyera coriacea, Renealmia alpinia, Stryphnodendron adstringens and Tabebuia caraiba were very active against T. rubrum, presented geometric means of the MIC values between 170.39 and 23.23 microg ml(-1). Extracts of Cerrado plants are of particular interest as source of new agents for the treatment of dermatophytic infections.
目前可用的抗真菌药物存在治疗局限性、真菌耐药性的发展、药物相关毒性、药物相互作用以及生物利用度不足等问题，因此有必要开发能够治疗新出现的真菌感染的药物。塞拉多是巴西第二大生物群落，被认为是南美洲最独特的生物群落之一，成为治疗多种病症的创新植物分子的重要来源。因此，本研究的目的是评估塞拉多植物的抗真菌潜力，主要是那些用于治疗感染和伤口的植物。通过琼脂孔扩散技术对总共57种提取物进行了针对白色念珠菌和红色毛癣菌的筛选。对最有前景的提取物进行较低浓度测试，并通过微量稀释法测定其最低抑菌浓度（MIC）。结果通过方差分析进行统计学分析。厚叶 Kielmeyera、高山蕾娜凤梨、收敛风车子和卡里巴风车子的提取物对红色毛癣菌非常有效，MIC值的几何平均值在170.39至23.23微克/毫升之间。塞拉多植物提取物作为治疗皮肤癣菌感染新药物的来源特别令人关注。
