Department of Pediatric Gastroenterology, Chang Gung Memorial Hospital, Taipei, Taiwan.
Hepatol Res. 2009 Feb;39(2):164-76. doi: 10.1111/j.1872-034X.2008.00413.x.
Hepatocellular carcinoma (HCC)-related protein-1 (HCRP1) gene was located at chromosome 8p22, a frequently deleted region in HCC. The gene product was a subunit of mammalian Endosomal Sorting Complex Required for Transport (ESCRT)-I, essential for degradation of epidermal growth factor receptors. In this study, we examined the prognostic role of HCRP1 mRNA expression in HCC.
The expression of HCRP1 mRNA in HCC was assessed in 125 patients receiving surgical resection of HCC. Using the adjacent non-cancerous tissues as a reference, 55 and 70 patients expressing high and low levels of HCRP1 mRNA, respectively, were identified. The predictive value of HCRP1 mRNA expression in postoperative survival was evaluated.
Expression of HCRP1 mRNA was not associated with any of the baseline clinicopathological parameters. However, univariate analysis showed that it was associated with a better disease-free survival (P < 0.001) and overall survival (P = 0.032). Stepwise Cox multivariate proportional hazards regression analysis showed that the expression of HCRP1 mRNA (hazard ratio [HR], 0.396; 95% confidence interval (CI), 0.233-0.674; P = 0.001), tumor number (HR, 1.596; 95% CI, 1.221-2.087; P = 0.001), serum aspartate aminotransferase (HR, 1.002; 95% CI, 1.000-1.003; P = 0.031) and the presence of microvascular invasion (HR, 1.852; 95% CI, 1.131-3.032; P = 0.014) were included as independent predictors for disease-free survival.
Expression of HCRP1 mRNA served as an independent predictor for postoperative disease-free survival in HCC patients.
肝细胞癌（HCC）相关蛋白-1（HCRP1）基因位于 8p22 染色体上，该区域是 HCC 中经常缺失的区域。该基因产物是人内体分选复合物必需的运输（ESCRT）-I 的亚基，对于表皮生长因子受体的降解至关重要。在这项研究中，我们检查了 HCRP1 mRNA 表达在 HCC 中的预后作用。
在 125 例接受 HCC 手术切除的患者中评估了 HCRP1 mRNA 的表达。使用相邻的非癌组织作为参考，分别确定 55 例和 70 例高和低 HCRP1 mRNA 表达的患者。评估 HCRP1 mRNA 表达在术后生存中的预测价值。
HCRP1 mRNA 的表达与任何基线临床病理参数均无关。然而，单因素分析显示，它与更好的无病生存率（P < 0.001）和总生存率（P = 0.032）相关。逐步 Cox 多变量比例风险回归分析显示，HCRP1 mRNA 的表达（危险比 [HR]，0.396；95%置信区间 [CI]，0.233-0.674；P = 0.001）、肿瘤数量（HR，1.596；95% CI，1.221-2.087；P = 0.001）、血清天门冬氨酸转氨酶（HR，1.002；95% CI，1.000-1.003；P = 0.031）和微血管侵犯的存在（HR，1.852；95% CI，1.131-3.032；P = 0.014）被纳入无病生存率的独立预测因素。
HCRP1 mRNA 的表达是 HCC 患者术后无病生存率的独立预测因子。
