孕期甲基多巴肝毒性

Alpha-methyldopa hepatotoxicity in pregnancy.

作者信息

Ali Tauseef, Srinivasan Nandakumar, Le Vu, Rizvi Syed

机构信息

Department of Gastroenterology, University of Oklahoma, Oklahoma City, USA.

出版信息

J Coll Physicians Surg Pak. 2009 Feb;19(2):125-6.

PMID:19208320

Abstract

A 12-week pregnant, 33-year-old African American female, presented with jaundice and change in urine colour. Liver function tests revealed raised transamines and normal alkaline phosphatase. She was started on methyldopa 6 weeks prior to presentation. After initial negative investigations including viral and autoimmune hepatitis, she was given prednisone for methyldopa induced hepatitis. Two weeks later, repeat enzymes revealed normal values. Important clinical and management points related to methyldopa induced hepatotoxicity are discussed.

摘要

一名怀孕12周、33岁的非裔美国女性，出现黄疸和尿液颜色改变。肝功能检查显示转氨酶升高，碱性磷酸酶正常。她在就诊前6周开始服用甲基多巴。在包括病毒性和自身免疫性肝炎在内的初步检查结果为阴性后，她因甲基多巴诱发的肝炎接受了泼尼松治疗。两周后，复查酶水平显示值正常。文中讨论了与甲基多巴诱发肝毒性相关的重要临床和管理要点。