Kashkooli Soleiman, Baraty Brandon, Kalantar Jamshid
Nepean Hospital, Sydney, New South Wales, Australia.
BMJ Case Rep. 2014 Feb 27;2014:bcr2014203712. doi: 10.1136/bcr-2014-203712.
A 34-year-old woman, with a history of pre-eclampsia, was diagnosed with α-methyldopa-induced hepatotoxicity, after she presented with severe jaundice and hepatitis 8 weeks following delivery. Laboratory investigations and liver biopsy ruled out other causes of hepatitis. She continued to improve clinically after cessation of α-methyldopa, and was discharged 10 days after admission. This case report emphasises that it may not be possible to predict which patients may develop α-methyldopa-induced hepatitis, hence regular monitoring of liver function tests during treatment should be implemented.
一名34岁有子痫前期病史的女性，在分娩8周后出现严重黄疸和肝炎，被诊断为甲基多巴诱发的肝毒性。实验室检查和肝活检排除了肝炎的其他病因。停用甲基多巴后，她的临床症状持续改善，入院10天后出院。本病例报告强调，可能无法预测哪些患者会发生甲基多巴诱发的肝炎，因此在治疗期间应定期监测肝功能检查。
