Morioka N, Tsuchida T, Ueda Y, Ishibashi Y
Department of Dermatology, Faculty of Medicine, University of Tokyo.
Nihon Hifuka Gakkai Zasshi. 1991 May;101(6):615-22.
We sent out a questionnaire to 47 patients of SLE and its similar diseases as to their past histories of chilblain. The results of the patients were compared to those of 141 cases of control. Although the percentage of cases who had revealed chilblain frequently (40.0%) and the age of chilblain onset (mean: 10.8 years old) in SLE group were not significantly different from those of control (28.4% and 12.4 years old, respectively), the chilblain which SLE patients developed had some characteristics compared to that of control, (1) higher incidence of chilblain episodes, (2) longer duration until cure, (3) more liability that chilblain leads to erosion or ulceration and (4) frequent occurrence of chilblain in the other seasons than winter. Especially SLE patients with the characteristic of (4) had higher association rates of Raynaud's phenomena, chilblain LE and livedo, suggesting disorder of peripheral circulation. It was also revealed that females are generally more liable to develop chilblain than males (females: 40.0%, males: 13.1%). Those results suggest some important relationship between chilblain and LE lesions. It is supposed that chilblain with the characteristics described above may possibly be transformed into LE lesions.
我们向47例系统性红斑狼疮（SLE）及其相似疾病患者发放了关于冻疮既往史的调查问卷。将患者的结果与141例对照病例的结果进行比较。虽然SLE组中经常出现冻疮的病例百分比（40.0%）和冻疮发病年龄（平均：10.8岁）与对照组（分别为28.4%和12.4岁）无显著差异，但SLE患者发生的冻疮与对照组相比有一些特点：（1）冻疮发作发生率更高；（2）治愈所需时间更长；（3）冻疮导致糜烂或溃疡的可能性更大；（4）除冬季外其他季节冻疮频发。尤其是具有特点（4）的SLE患者雷诺现象、冻疮样红斑狼疮和青斑的关联率更高，提示外周循环障碍。还发现女性一般比男性更容易发生冻疮（女性：40.0%，男性：13.1%）。这些结果提示冻疮与红斑狼疮皮损之间存在一些重要关系。推测具有上述特点的冻疮可能会转化为红斑狼疮皮损。
