Department of Dermatology, Hospital Clinic, University of Barcelona, Catalonia, Spain.
Clin Exp Dermatol. 2010 Oct;35(7):729-35. doi: 10.1111/j.1365-2230.2009.03764.x.
Numerous studies involving systemic lupus erythematosus (SLE) have attempted to identify gender differences in patients with lupus erythematosus (LE). However, few reports on cutaneous lupus erythematous (CLE) have identified gender differences.
To analyse and compare the prevalence and characteristics of the main clinical and immunological features of male and female patients with CLE.
The medical records of 103 (33.4%) male and 205 (66.6%) female patients with CLE who were treated as inpatients or outpatients between January 1985 and December 2000 were retrospectively studied. All patients were reviewed in detail stratified by a predefined protocol.
Female patients had a higher prevalence of Raynaud's phenomenon (P < 0.01), chilblain lupus (P = 0.005), arthralgias (P = 0.001) and SLE (P < 0.01). Female patients were also more likely to have an increased erythrocyte sedimentation rate (P < 0.005), higher levels of antinuclear antibodies (P < 0.001) and decreased levels of C3 (P < 0.001), C4 (P < 0.01) and CH50 (P < 0.01). There was a higher prevalence of clinical and laboratory abnormalities in female patients who had both SLE and CLE than in male patients with both conditions. Conclusions. In our series, differences in the expression of CLE existed between male and female patients with respect to the type of lesions, systemic features, and immunological findings.
许多涉及系统性红斑狼疮（SLE）的研究试图确定狼疮患者的性别差异。然而，关于皮肤红斑狼疮（CLE）的报道很少确定性别差异。
分析和比较男性和女性 CLE 患者主要临床和免疫特征的患病率和特征。
回顾性研究了 1985 年 1 月至 2000 年 12 月期间住院或门诊治疗的 103 名（33.4%）男性和 205 名（66.6%）女性 CLE 患者的病历。根据预先确定的方案详细审查所有患者。
女性患者雷诺现象（P < 0.01）、冻疮样狼疮（P = 0.005）、关节痛（P = 0.001）和 SLE（P < 0.01）的患病率较高。女性患者血沉（P < 0.005）、抗核抗体水平（P < 0.001）升高，C3（P < 0.001）、C4（P < 0.01）和 CH50（P < 0.01）水平降低的可能性也更高。患有 SLE 和 CLE 的女性患者比患有两种疾病的男性患者更常出现临床和实验室异常。结论。在我们的系列中，CLE 患者的性别差异存在于病变类型、全身特征和免疫发现方面。
