Ostap E Michael
Department of Physiology, University of Pennsylvania School of Medicine, B400 Richards Building, Philadelphia, PA 19104-6085, USA.
Adv Exp Med Biol. 2008;644:273-82. doi: 10.1007/978-0-387-85766-4_20.
Vertebrate nonmuscle cells express multiple tropomyosin isoforms that are sorted to subcellular compartments that have distinct morphological and dynamic properties. The creation of these compartments has a role in controlling cell morphology, cell migration and polarization of cellular components. There is increasing evidence that nonmuscle myosins are regulated by tropomyosin in these compartments via the regulation of actin attachment, ATPase kinetics, or by stabilization of cytoskeletal tracks for myosin-based transport. In this chapter, I review the literature describing the regulation of various myosins by tropomyosins and consider the mechanisms for this regulation.
脊椎动物的非肌肉细胞表达多种原肌球蛋白异构体，这些异构体被分选到具有不同形态和动态特性的亚细胞区室中。这些区室的形成在控制细胞形态、细胞迁移和细胞成分极化方面发挥作用。越来越多的证据表明，在这些区室中，非肌肉肌球蛋白通过调节肌动蛋白附着、ATP酶动力学或通过稳定基于肌球蛋白运输的细胞骨架轨道，受原肌球蛋白调控。在本章中，我回顾了描述原肌球蛋白对各种肌球蛋白调控的文献，并思考了这种调控的机制。
