Heterobimetallic lanthanide/sodium phenoxides: efficient catalysts for amidation of aldehydes with amines.

作者信息

Li Junmei, Xu Fan, Zhang Yong, Shen Qi

机构信息

Key Laboratory of Organic Synthesis of Jiangsu Province, Department of Chemistry and Chemical Engineering, Dushu Lake Campus, Suzhou University, Suzhou 215123, People's Republic of China.

出版信息

J Org Chem. 2009 Mar 20;74(6):2575-7. doi: 10.1021/jo802617d.

DOI:10.1021/jo802617d

PMID:19209872

Abstract

Heterobimetallic lanthanide/sodium phenoxides were found to be efficient catalysts for amidation of aldehydes with amines under mild conditions. The reactivity follows the order Nd < Y < Sm for metals and 2,6-(Me)2C6H3O < 2,6-(iPr)2C6H3O < 2,6-(tBu)2C6H3O for phenoxide groups. In comparison with the corresponding monometallic complexes, heterobimetallic complexes show higher activity and a wider range of scope of amines. A cooperation of lanthanide and sodium in this process is proposed to contribute to the high activity of the present catalyst.

摘要