Department of Chemistry and School of Molecular Science (BK21), Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Korea.
Org Lett. 2009 Mar 5;11(5):1155-8. doi: 10.1021/ol900023t.
Alpha-aryl beta-hydroxy imidates are efficiently obtained by the four-component reaction of ethyl glyoxylates, aryl acetylenes, sulfonyl azides, and alcohols using a copper catalyst. The developed procedure is characterized by high selectivity, mild reaction conditions, a wide substrate scope, and an excellent functional group tolerance. Facile transformations of the obtained sulfonylimidate moiety to other carbonyl groups such as sulfonamides or esters were also demonstrated.
通过使用铜催化剂，由乙基乙二醛、芳基乙炔、磺酰基叠氮化物和醇的四组分反应，高效地得到了α-芳基β-羟基亚氨基酯。所开发的方法具有高选择性、温和的反应条件、广泛的底物范围和出色的官能团耐受性。还证明了获得的磺酰亚氨基酯部分很容易转化为其他羰基化合物，如磺酰胺或酯。
