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治疗性保湿剂作为银屑病患者的辅助治疗。

Therapeutic moisturizers as adjuvant therapy for psoriasis patients.

机构信息

Istituto di Scienze Dermatologiche, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy.

出版信息

Am J Clin Dermatol. 2009;10 Suppl 1:7-12. doi: 10.2165/0128071-200910001-00002.

Abstract

At any point in time, psoriasis affects 2-3% of the world's population and has one of the biggest impacts on quality of life of any dermatological disorder. Treatment is extremely costly and prevention of disease progression in severity and extent is crucial. Psoriasis treatment should include skin hydration (regular use of moisturizers and emollients), careful, gentle skin cleansing, and identification and avoidance of Koebner phenomenon triggers (excoriation, maceration) and infectious foci (Streptococcus pyogenes). Moisturizers have been shown to significantly improve skin conditions and quality of life for psoriasis patients. They are a valuable first-line treatment, as dry skin is common and adds to the irritability of the diseased skin. Most patients respond well to topical treatment with topical corticosteroids, emollients, coal tar, anthralin (dithranol) or calcipotriol. Emollients are the most prescribed products, providing transient relief from irritation and some possessing anti-inflammatory properties. Moisturizers and emollients should be used in the following cases: minimal psoriasis, napkin psoriasis, psoriasis of the folds, psoriatic skin damaged by previous local treatments, and in pregnancy or women of childbearing age.

摘要

在任何时候,银屑病影响世界人口的 2-3%,是对任何皮肤病生活质量影响最大的疾病之一。治疗费用极高,预防疾病严重程度和范围的进展至关重要。银屑病的治疗应包括皮肤保湿(定期使用保湿剂和润滑剂)、小心温和的皮肤清洁以及识别和避免科布纳现象触发因素(搔抓、浸渍)和感染病灶(化脓性链球菌)。保湿剂已被证明可显著改善银屑病患者的皮肤状况和生活质量。它们是一种有价值的一线治疗方法,因为干燥的皮肤很常见,会增加患病皮肤的敏感性。大多数患者对局部皮质类固醇、润滑剂、煤焦油、蒽林(地蒽酚)或卡泊三醇等局部治疗反应良好。润滑剂是最常开的药物,可暂时缓解刺激,有些还具有抗炎作用。保湿剂和润滑剂应在以下情况下使用:轻度银屑病、尿布银屑病、褶皱处银屑病、以前局部治疗导致的银屑病皮肤损伤,以及在妊娠或育龄妇女中使用。

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