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Cryptococcus neoformans activates bone marrow-derived conventional dendritic cells rather than plasmacytoid dendritic cells and down-regulates macrophages.新型隐球菌激活骨髓来源的传统树突状细胞而非浆细胞样树突状细胞，并下调巨噬细胞。
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Innate control of adaptive immunity: dendritic cells and beyond.适应性免疫的固有调控：树突状细胞及其他
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Spherules derived from Coccidioides posadasii promote human dendritic cell maturation and activation.源自波萨达斯球孢子菌的球形体可促进人类树突状细胞的成熟和激活。
Infect Immun. 2006 Apr;74(4):2415-22. doi: 10.1128/IAI.74.4.2415-2422.2006.
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Cytokines and lymphocyte proliferation in patients with different clinical forms of chromoblastomycosis.不同临床类型着色芽生菌病患者的细胞因子与淋巴细胞增殖
Microbes Infect. 2005 Apr;7(4):708-13. doi: 10.1016/j.micinf.2005.01.006. Epub 2005 Mar 21.
5
Innate immunity to the pathogenic fungus Coccidioides posadasii is dependent on Toll-like receptor 2 and Dectin-1.对致病性真菌波萨达斯球孢子菌的天然免疫依赖于Toll样受体2和Dectin-1。
Infect Immun. 2005 Mar;73(3):1553-60. doi: 10.1128/IAI.73.3.1553-1560.2005.
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Mannoproteins from Cryptococcus neoformans promote dendritic cell maturation and activation.新型隐球菌的甘露糖蛋白可促进树突状细胞的成熟和激活。
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Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin mediates binding and internalization of Aspergillus fumigatus conidia by dendritic cells and macrophages.树突状细胞特异性细胞间黏附分子3结合非整合素介导烟曲霉分生孢子与树突状细胞和巨噬细胞的结合及内化。
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Chromoblastomycosis caused by Rhinocladiella aquaspersa.由水栖枝孢霉引起的着色芽生菌病。
Med Mycol. 2004 Jun;42(3):261-5. doi: 10.1080/13693780310001597700.
9
Isolation of Fonsecaea pedrosoi from thorns of Mimosa pudica, a probable natural source of chromoblastomycosis.从含羞草刺中分离出裴氏瓶霉，含羞草可能是着色芽生菌病的天然来源。
Rev Inst Med Trop Sao Paulo. 2004 Jan-Feb;46(1):33-6. doi: 10.1590/s0036-46652004000100006. Epub 2004 Mar 29.
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Immunity to fungal infections.对真菌感染的免疫力
Nat Rev Immunol. 2004 Jan;4(1):1-23. doi: 10.1038/nri1255.

来自重度着色芽生菌病患者的单核细胞衍生树突状细胞在体外可诱导CD4+ T细胞活化。

Monocyte-derived dendritic cells from patients with severe forms of chromoblastomycosis induce CD4+ T cell activation in vitro.

作者信息

Sousa M Glória, Ghosn E Eid Bou, Nascimento R Ciciro, Bomfim G Facchioli, Noal V, Santiago K, de Maria Pedrozo E Silva Azevedo C, Marques S Garcia, Gonçalves A Guedes, de Castro Lima Santos D Wagner, Criado P Ricardo, Costa Martins J Eduardo, Almeida S Rogerio

机构信息

Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de Sao Paulo, SP, Brazil.

出版信息

Clin Exp Immunol. 2009 Apr;156(1):117-25. doi: 10.1111/j.1365-2249.2008.03870.x. Epub 2009 Feb 4.

DOI:10.1111/j.1365-2249.2008.03870.x
PMID:19210522
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2673749/
Abstract

Dendritic cells (DCs) have been described as initiators and modulators of the immune response. Recently we have shown a predominant production of interleukin-10 cytokine, low levels of interferon-gamma and inefficient T cell proliferation in patients with severe forms of chromoblastomycosis. Chromoblastomycosis starts with subcutaneous inoculation of Fonsecaea pedrosoi into tissue where DCs are the first line of defence against this microorganism. In the present study, the interaction of F. pedrosoi and DCs obtained from patients with chromoblastomycosis was investigated. Our results showed that DCs from patients exhibited an increased expression of human leucocyte antigen D-related (HLA-DR) and co-stimulatory molecules. In the presence of conidia, the expression of HLA-DR and CD86 was up-regulated by DCs from patients and controls. Finally, we demonstrate the reversal of antigen-specific anergy and a T helper type 1 response mediated by DCs incubated with F. pedrosoi conidea.

摘要

树突状细胞（DCs）被认为是免疫反应的启动者和调节者。最近我们发现，在重症着色芽生菌病患者中，白细胞介素-10细胞因子大量产生，γ干扰素水平较低，且T细胞增殖效率低下。着色芽生菌病始于裴氏着色真菌经皮下接种进入组织，在此过程中，DCs是抵御这种微生物的第一道防线。在本研究中，我们调查了裴氏着色真菌与取自着色芽生菌病患者的DCs之间的相互作用。我们的结果显示，来自患者的DCs表现出人类白细胞抗原D相关分子（HLA-DR）和共刺激分子的表达增加。在分生孢子存在的情况下，来自患者和对照的DCs均使HLA-DR和CD86的表达上调。最后，我们证明了与裴氏着色真菌分生孢子共同孵育的DCs介导的抗原特异性无反应性的逆转以及1型辅助性T细胞反应。