Kljakovic Marjan, Gatenby Paul, Hawkins Carolyn, Attewell Robyn G, Ciszek Karen, Kratochvil Gitta, Moreira Alayne, Ponsonby Anne-Louise
Australian National University Medical School, Australian Capital Territory, Australia.
J Paediatr Child Health. 2009 Mar;45(3):98-103. doi: 10.1111/j.1440-1754.2008.01436.x. Epub 2008 Feb 2.
To describe parent-reported prevalence and management of peanut and nut allergy in school entrant children.
A population-based, cross-sectional study in the Australian National Capital.
Out of 3851 children, parents reported 127 had a strong allergic reaction to peanuts and 19 to other nuts ever. Nut allergy ever prevalence was 3.8% (95% confidence interval 3.2-4.4%), and of peanut allergy ever 3.3% (2.8-3.9%). Children with nut allergy were more likely to have a general practitioner (odds ratio 2.64, 1.16-6.03), hay fever (3.78, 2.67-5.36), eczema (4.54, 3.15-6.56) and wheeze in the last 12 months (3.19, 2.22-4.59) and have been breastfed (2.68, 1.26-5.77) than those who did not. At follow up of 109 children with parent-reported allergy (75% response), 70% had diagnostic test-confirmed sensitisation, 32% had been prescribed an adrenalin autoinjector (6% had used one) and 46% were not eating peanut. Increasing severity of reported symptoms following consumption of peanut was associated with an increasing likelihood of recommended management. Based on parent report, the projected estimated diagnostic test-confirmed prevalence of peanut sensitisation was 2.4% (1.9%, 3.0%) for the entire sample.
Among a highly representative sample of children at school entry, 1 in 30 parents reported their child to have a strong allergic reaction to nuts and over 1 in 50 are estimated to have diagnostic test-confirmed peanut sensitisation, based on parent report.
描述家长报告的入学儿童花生和坚果过敏的患病率及管理情况。
在澳大利亚首都地区进行的一项基于人群的横断面研究。
在3851名儿童中,家长报告有127名儿童曾对花生有强烈过敏反应,19名儿童曾对其他坚果有强烈过敏反应。坚果过敏的既往患病率为3.8%(95%置信区间3.2 - 4.4%),花生过敏的既往患病率为3.3%(2.8 - 3.9%)。与无坚果过敏的儿童相比,有坚果过敏的儿童更有可能有全科医生(优势比2.64,1.16 - 6.03)、花粉症(3.78,2.67 - 5.36)、湿疹(4.54,3.15 - 6.56),在过去12个月内有喘息(3.19,2.22 - 4.59),并且曾接受母乳喂养(2.68,1.26 - 5.77)。在对109名家长报告有过敏的儿童进行随访时(应答率75%),70%的儿童诊断测试确诊为致敏,32%的儿童被开了肾上腺素自动注射器(6%使用过),46%的儿童不吃花生。食用花生后报告症状的严重程度增加与推荐管理的可能性增加相关。根据家长报告,整个样本中预计诊断测试确诊的花生致敏患病率为2.4%(1.9%,3.0%)。
在极具代表性的入学儿童样本中,根据家长报告,30名家长中有1名报告其孩子对坚果有强烈过敏反应,估计每50多名家长中有1名孩子诊断测试确诊为花生致敏。