Uchiyama Michihiro, Nagao Tsuyoshi, Hattori Aritoshi, Fujii Tatsuya, Ichiwata Toshio, Nakata Koh, Tani Kenzaburo, Hayashi Takuya
Department of Advanced Molecular Cell Therapy, Kyushu University, Fukuoka, Japan.
Respirology. 2009 Mar;14(2):305-8. doi: 10.1111/j.1440-1843.2008.01450.x. Epub 2008 Dec 11.
Secondary pulmonary alveolar proteinosis (PAP) has been described in several clinical settings that can be grouped into three main categories: infections of the lung; haematological malignancies and other conditions that alter the patient's immune status; and exposure to inhaled chemicals and minerals. Recent studies reported that anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) antibody was present in the serum of patients with idiopathic PAP but not in patients with secondary PAP or in normal subjects. The present report describes the interesting case of a patient with Behcet's disease and PAP. The absence of anti-GM-CSF antibodies in this patient suggested a diagnosis of secondary PAP.
继发性肺泡蛋白沉积症（PAP）已在多种临床情况下被描述，可分为三大类：肺部感染；血液系统恶性肿瘤及其他改变患者免疫状态的疾病；以及接触吸入性化学物质和矿物质。最近的研究报告称，特发性PAP患者血清中存在抗粒细胞-巨噬细胞集落刺激因子（GM-CSF）抗体，而继发性PAP患者或正常受试者血清中则不存在。本报告描述了一例患有白塞病和PAP的患者的有趣病例。该患者缺乏抗GM-CSF抗体提示诊断为继发性PAP。
