将神经元的概率发放视为首次通过问题。
Probabilistic firing of neurons considered as a first passage problem.
作者信息
Hoopen M T
机构信息
Institute of Medical Physics TNO, Utrecht, The Netherlands.
出版信息
Biophys J. 1966 Jul;6(4):435-51. doi: 10.1016/S0006-3495(66)86668-7. Epub 2008 Dec 31.
Abstract
A formalized neuron receiving unitary excitatory impulses at random is considered. Each impulse provokes an effect of equal magnitude and of a duration not constant for each impulse, but which varies according to an exponential distribution. The effects sum until a threshold is reached when a response occurs. The distribution of intervals between successive responses is computed and compared with those obtained from a model in which the effects decay exponentially with time. Upon introducing inhibitory impulses also, the theory is applied to data on discharge characteristics of driven and spontaneously active thalamic neurons reported in the literature.
摘要
考虑一个形式化的神经元，它随机接收单一的兴奋性冲动。每个冲动引发的效应大小相等，且每个冲动的持续时间并非恒定不变，而是根据指数分布变化。这些效应不断累加，直至达到阈值时产生反应。计算连续反应之间的间隔分布，并与从一个模型中获得的间隔分布进行比较，在该模型中效应随时间呈指数衰减。在引入抑制性冲动后，该理论被应用于文献中报道的驱动性和自发性活动的丘脑神经元放电特性的数据。
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