Spulber Stefan, Mateos Laura, Oprica Mircea, Cedazo-Minguez Angel, Bartfai Tamas, Winblad Bengt, Schultzberg Marianne
Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
J Neuroimmunol. 2009 Mar 31;208(1-2):46-53. doi: 10.1016/j.jneuroim.2009.01.010. Epub 2009 Feb 10.
Interleukin-1 (IL-1) is expressed following LTP induction and is required for long-term memory consolidation. We demonstrate that the long-term, but not short-term memory is impaired in a transgenic mouse strain overexpressing the human soluble interleukin-1 receptor antagonist (hsIL-1ra) in the brain. Overexpression of IL-1ra was found to reduce the basal as well as the novelty-induced upregulation of activity-regulated cytoskeleton-associated protein (Arc) in the dentate gyrus and in the retrosplenial cortex. Together with the finding that blocking IL-1 receptors interferes with the BDNF-ERK1/2 pathway, our data suggest an essential role played by physiological levels of IL-1 in long-term memory consolidation.
白细胞介素-1（IL-1）在长时程增强（LTP）诱导后表达，并且是长期记忆巩固所必需的。我们证明，在大脑中过表达人可溶性白细胞介素-1受体拮抗剂（hsIL-1ra）的转基因小鼠品系中，长期记忆而非短期记忆受损。发现IL-1ra的过表达会降低齿状回和脾后皮质中基础以及新奇诱导的活性调节细胞骨架相关蛋白（Arc）的上调。连同阻断IL-1受体会干扰脑源性神经营养因子（BDNF）-细胞外信号调节激酶1/2（ERK1/2）途径这一发现，我们的数据表明生理水平的IL-1在长期记忆巩固中起重要作用。
