Riordan J F
Ann Clin Lab Sci. 1977 Mar-Apr;7(2):119-29.
Metal ions play important roles in the biological function of many enzymes. The various modes of metal-protein interaction include metal-, ligand-, and enzyme-bridge complexes. Metals can serve as electron donors or acceptors, Lewis acids or structural regulators. Those that participate directly in the catalytic mechanism usually exhibit anomalous physicochemical characteristics reflecting their entatic state. Carboxypeptidase A, liver alcohol dehydrogenase, aspartate transcarbamoylase and alkaline phosphatase exemplify the different roles of metals in metalloenzymes while the nucleotide polymerases point to the essential role of zinc in maintaining normal growth and development.
金属离子在许多酶的生物学功能中发挥着重要作用。金属与蛋白质相互作用的各种模式包括金属桥、配体桥和酶桥复合物。金属可以作为电子供体或受体、路易斯酸或结构调节剂。那些直接参与催化机制的金属通常表现出异常的物理化学特性，反映出它们的内稳态。羧肽酶A、肝脏乙醇脱氢酶、天冬氨酸转氨甲酰酶和碱性磷酸酶例证了金属在金属酶中的不同作用，而核苷酸聚合酶则表明锌在维持正常生长发育中的重要作用。
