Pregant P, Schernthaner G, Legenstein E, Lienhart L, Bruck S, Schnack C, Kaiser E
Institut für Medizinische Chemie, Universität Wien.
Klin Wochenschr. 1991 Aug 16;69(12):511-6. doi: 10.1007/BF01649287.
Realizing the importance of carnitine for the lipid and carbohydrate metabolism and the possible role for glucose utilization and myocardial function carnitine concentrations in type I and type II diabetic patients in plasma, erythrocytes and 24 h urine were determined. The plasma levels of carnitine were significantly diminished in type I diabetic patients compared to controls, while carnitine concentrations in erythrocytes and 24 h urine did not differ from controls. Plasma carnitine levels did not change significantly during the diurnial profile. No correlation between HbA1c and carnitine levels was observed in the diabetic patients.
认识到肉碱对脂质和碳水化合物代谢的重要性以及对葡萄糖利用和心肌功能的可能作用，我们测定了Ⅰ型和Ⅱ型糖尿病患者血浆、红细胞和24小时尿液中的肉碱浓度。与对照组相比，Ⅰ型糖尿病患者血浆中的肉碱水平显著降低，而红细胞和24小时尿液中的肉碱浓度与对照组无差异。血浆肉碱水平在昼夜变化过程中无显著变化。在糖尿病患者中未观察到糖化血红蛋白（HbA1c）与肉碱水平之间的相关性。
