核心蛋白聚糖在食管癌中的表达与转化生长因子-β三种同工型（转化生长因子-β1、-β2和-β3）的表达及基质金属蛋白酶-2活性的关系

Expression of decorin in esophageal cancer in relation to the expression of three isoforms of transforming growth factor-beta (TGF-beta1, -beta2, and -beta3) and matrix metalloproteinase-2 activity.

作者信息

Augoff K, Grabowski K, Rabczynski J, Kolondra A, Tabola R, Sikorski A F

机构信息

Department of Gastrointestinal and General Surgery, University of Wroclaw, Poland.

出版信息

Cancer Invest. 2009 May;27(4):443-52. doi: 10.1080/07357900802527221.

DOI:10.1080/07357900802527221

PMID:19212830

Abstract

To determine the role of the reactive stroma in cancer progression, we investigated decorin (DCN) and transforming growth factor-beta (TGF-beta expression, and matrix metalloproteinase-2 (MMP-2) activity in the tumorous esophagus. We found statistically insignificantly decreased levels of DCN expression in the pathological tissues. No obvious alterations in TGF-beta expression were noticed. The highly significant increase in MMP-2 activity in cancers did not result in elevated levels of TGF-beta dimers. Therefore, the system of TGF-beta liberation from its complex with DCN by activated MMP-2 does not seem to contribute to esophageal cancerogenesis, although this hypothesis should be reevaluated with a larger study group.

摘要

为了确定反应性基质在癌症进展中的作用，我们研究了食管肿瘤中核心蛋白聚糖（DCN）、转化生长因子-β（TGF-β）的表达以及基质金属蛋白酶-2（MMP-2）的活性。我们发现病理组织中DCN表达水平的降低在统计学上无显著意义。未观察到TGF-β表达有明显变化。癌症中MMP-2活性的显著增加并未导致TGF-β二聚体水平升高。因此，尽管这一假设应通过更大的研究组重新评估，但由活化的MMP-2将TGF-β从其与DCN的复合物中释放出来的系统似乎对食管癌发生没有作用。