Zhao Chenxi, Zeng Yingxu, Wan Mingzhu, Li Rongxi, Liang Yizeng, Li Chengyong, Zeng Zhongda, Chau Foo-Tim
Chemometrics and Herbal Medicine Laboratory, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, PR China.
J Sep Sci. 2009 Feb;32(4):660-70. doi: 10.1002/jssc.200800484.
Systematic comparative research was conducted on essential oils from eight traditional Chinese medicines (TCM) of pungent flavor and cool nature because the essential oils are the main active ingredients of herbs of this kind. The work was based on their component analysis by gas chromatography-mass spectrometry (GC-MS), on their retention indices, as well as on chemometric resolution methods. A total of 144 compounds were tentatively identified, accounting for 69.0% to 91.8% of the total essential oils. It is worth noting that there are 67 compounds in at least three of these eight essential oils. Moreover, many biologically active compounds, such as hexanal, alpha-pinene, camphene, beta-pinene, p-cymene, limonene, eucalyptol, (Z)-ocimene, gamma-terpinene, camphor, p-menthone, 4-terpineol, alpha-terpineol, carvone, eugenol, caryophyllene, beta-farnesene, alpha-curcumene, beta-selinene, delta-cadinene, caryophyllene oxide, cedrol, n-hexadecanoic acid, benzaldehyde, benzeneacetaldehyde, phthalic acid diisobutyl ester, linoleic acid, tetradecanoic acid, (Z,Z,Z)-9,12,15-octadecatrienoic acid, eucalyptol, pentadecanoic acid, hexadecanoic acid methyl ester, linoleic acid methyl ester, exist in at least four of the eight essential oils. These results might help us to understand why the eight herbs are all of pungent flavor and cool nature according to the theory of TCM, and may provide a useful chemical basis for future research on herbs of this kind.
对8种辛味寒凉性传统中药的挥发油进行了系统的比较研究，因为挥发油是这类中药的主要活性成分。这项工作基于气相色谱-质谱联用（GC-MS）对其成分的分析、保留指数以及化学计量学解析方法。共初步鉴定出144种化合物，占挥发油总量的69.0%至91.8%。值得注意的是，这8种挥发油中至少有3种含有67种化合物。此外，许多生物活性化合物，如己醛、α-蒎烯、莰烯、β-蒎烯、对伞花烃、柠檬烯、桉叶油素、（Z）-罗勒烯、γ-松油烯、樟脑、对薄荷酮、4-松油醇、α-松油醇、香芹酮、丁香酚、石竹烯、β-法尼烯、α-姜黄烯、β-芹子烯、δ-杜松烯、石竹烯氧化物、雪松醇、正十六烷酸、苯甲醛、苯乙醛、邻苯二甲酸二异丁酯、亚油酸、十四烷酸、（Z,Z,Z）-9,12,15-十八碳三烯酸、桉叶油素、十五烷酸、十六烷酸甲酯、亚油酸甲酯，存在于8种挥发油中的至少4种中。这些结果可能有助于我们理解为什么根据中医理论这8种中药均为辛味寒凉性，并可能为今后此类中药的研究提供有用的化学依据。
