Heim Markus, Keerl David, Scheibel Thomas
Lehrstuhl für Biomaterialien, Fakultät für Angewandte Naturwissenschaften, Universität Bayreuth, 95440 Bayreuth, Germany.
Angew Chem Int Ed Engl. 2009;48(20):3584-96. doi: 10.1002/anie.200803341.
Spider silks outrival natural and many synthetic fibers in terms of their material characteristics. In nature, the formation of a solid fiber from soluble spider silk proteins is the result of complex biochemical and physical processes that take place within specialized spinning organs. Herein, we present natural and artificial silk production processes, from gene transcription to silk protein processing and finally fiber assembly. In-vivo and in-vitro findings in the field of spider silk research are the basis for the design of new proteins and processing strategies, which will enable applications of these fascinating protein-based materials in technical and medical sciences.
蜘蛛丝在材料特性方面优于天然纤维和许多合成纤维。在自然界中，由可溶性蜘蛛丝蛋白形成固体纤维是在专门的纺丝器官内发生的复杂生化和物理过程的结果。在此，我们展示了从基因转录到丝蛋白加工再到最终纤维组装的天然和人工丝生产过程。蜘蛛丝研究领域的体内和体外研究结果是设计新蛋白质和加工策略的基础，这将使这些迷人的蛋白质基材料能够应用于技术和医学科学领域。
