Chung Ying Kit, Fu Gregory C
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Angew Chem Int Ed Engl. 2009;48(12):2225-7. doi: 10.1002/anie.200805377.
Chiral phosphepine 1 catalyzes the transformation of an array of hydroxy-2-alkynoates into saturated oxygen heterocycles with good enantioselectivity. Phenols are also shown to participate in such phosphine-catalyzed cyclizations, including an asymmetric variant. This method provides a new approach to the enantioselective synthesis of tetrahydrofurans, tetrahydropyrans, and dihydrobenzopyrans.
手性磷杂环戊二烯1能以良好的对映选择性催化一系列羟基-2-炔酸酯转化为饱和氧杂环化合物。酚类化合物也被证明可参与此类磷催化的环化反应,包括不对称变体。该方法为对映选择性合成四氢呋喃、四氢吡喃和二氢苯并吡喃提供了一种新途径。