Iuga Aurel, Lerner Ethan, Shedd Tommy R, van der Schalie William H
Cutaneous Biology Research Center, Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA 02129, USA.
J Appl Toxicol. 2009 May;29(4):346-9. doi: 10.1002/jat.1416.
We have evaluated a Xenopus cell line as a potential sensor for detecting toxins in water. X. laevis melanophores responded rapidly by dispersing melanosomes following exposure to six (ammonia, arsenic, copper, mercury, pentachlorophenol and phenol) of 12 tested chemicals in the desired sensitivity range. For two additional chemicals (nicotine and paraquat) the melanophore response improved upon the response capabilities of several available toxicity sensors. These results suggest that a melanophore-based sensor could be useful for the rapid assessment of chemical toxicity in drinking water.
我们评估了一种非洲爪蟾细胞系作为检测水中毒素的潜在传感器。在暴露于12种受试化学物质中的6种（氨、砷、铜、汞、五氯苯酚和苯酚）且处于所需灵敏度范围内时，非洲爪蟾的黑素细胞会通过分散黑素小体迅速做出反应。对于另外两种化学物质（尼古丁和百草枯），黑素细胞的反应比几种现有的毒性传感器的反应能力有所提高。这些结果表明，基于黑素细胞的传感器可能有助于快速评估饮用水中的化学毒性。
