Cejas D, Almuzara M, Santella G, Tuduri A, Palombarani S, Figueroa S, Gutkind G, Radice M
Cátedra de Microbiología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina.
Rev Argent Microbiol. 2008 Oct-Dec;40(4):238-45.
From 129 P. aeruginosa isolated at a health care centre located in Buenos Aires (Hospital "Eva Perón"), 14% produced IMP-13. Although 18 isolates were metallo-beta-lactamases (MBL) producers, only those isolates that displayed altered outer membrane protein profiles correlated with the resistant category according to CLSI or even Subcomisión de Antimicrobianos, SADEBAC, AAM. Phenotypic screening of metallo-beta-lactamases proved to be appropriate for detecting MBL producing isolates. IMP-13 producing isolates corresponded to at least five different clonal types, which not only suggests the dissemination of the resistant strain but also of the resistant marker.
从布宜诺斯艾利斯一家医疗中心（“伊娃·庇隆医院”）分离出的129株铜绿假单胞菌中，14%产生IMP-13。尽管有18株分离菌是金属β-内酰胺酶（MBL）产生菌，但根据CLSI甚至抗菌药物小组委员会SADEBAC、AAM的标准，只有那些外膜蛋白谱发生改变的分离菌与耐药类别相关。金属β-内酰胺酶的表型筛选被证明适用于检测产生MBL的分离菌。产生IMP-13的分离菌至少对应五种不同的克隆类型，这不仅表明耐药菌株的传播，也表明耐药标记的传播。
