Stehmeier Per, Muller Stefan
Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany.
DNA Repair (Amst). 2009 Apr 5;8(4):491-8. doi: 10.1016/j.dnarep.2009.01.002. Epub 2009 Feb 12.
p53 and its cousins p63 and p73 are critical regulators of the genotoxic stress response in mammalian cells. Their activity is controlled by an intricate network of post-translational modifications. The ubiquitin-like SUMO system targets all three family members and modulates their transcriptional activity, stability or subcellular trafficking. While the SUMO system appears to primarily exert a negative regulatory function on p73 and p63, both activating and repressing activities have been reported on p53. Here we will give a synopsis of the multifaceted effects of SUMO on p53 family members.
p53及其同源蛋白p63和p73是哺乳动物细胞基因毒性应激反应的关键调节因子。它们的活性由一个复杂的翻译后修饰网络控制。类泛素化小泛素样修饰物（SUMO）系统作用于所有这三个家族成员，并调节它们的转录活性、稳定性或亚细胞运输。虽然SUMO系统似乎主要对p73和p63发挥负调节功能，但关于p53既有激活活性也有抑制活性的报道。在此，我们将概述SUMO对p53家族成员的多方面影响。
