Ge Xinyu, Zhang Ke, Zhu Jie, Chen Yuan, Wang Zhengwang, Wang Peng, Xu Peng, Yao Jie
Department of Hepatobiliary and Pancreatic Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Jiangsu 225000, China.
The Yangzhou School of Clinical Medicine of Dalian Medical University, Jiangsu 225000, China.
Int J Biol Sci. 2025 Jan 1;21(1):63-74. doi: 10.7150/ijbs.101861. eCollection 2025.
Post-translational modifications (PTMs) alter protein conformation by covalently attaching functional groups to substrates, influencing their biological activity, mechanisms of action, and functional performance. PTMs and their interactions are essential to many critical signal transduction processes, including tumor transformation, cancer progression, and metastasis in pancreatic cancer. Additionally, advancements in tumor immunotherapy indicate that PTMs are essential in immune cell activation, transport, and energy metabolism. This study aimed to investigate the effects of different PTMs on immunotherapy for pancreatic cancer, providing new perspectives and suggesting directions for future research.
翻译后修饰（PTMs）通过将官能团共价连接到底物上来改变蛋白质构象，影响其生物学活性、作用机制和功能表现。PTMs及其相互作用对于许多关键的信号转导过程至关重要，包括胰腺癌中的肿瘤转化、癌症进展和转移。此外，肿瘤免疫疗法的进展表明，PTMs在免疫细胞激活、运输和能量代谢中至关重要。本研究旨在探讨不同PTMs对胰腺癌免疫治疗的影响，为未来研究提供新的视角并指明方向。
