在抗逆转录病毒治疗抑制期，CCR5-Δ32杂合子中1型人类免疫缺陷病毒转录减少。
Decreased HIV type 1 transcription in CCR5-Δ32 heterozygotes during suppressive antiretroviral therapy.
作者信息
Wang Charlene, Abdel-Mohsen Mohamed, Strain Matthew C, Lada Steven M, Yukl Steven, Cockerham Leslie R, Pilcher Christopher D, Hecht Frederick M, Sinclair Elizabeth, Liegler Teri, Richman Douglas D, Deeks Steven G, Pillai Satish K
机构信息
Emory University, Atlanta, Georgia Blood Systems Research Institute.
Blood Systems Research Institute University of California-San Francisco.
出版信息
J Infect Dis. 2014 Dec 1;210(11):1838-43. doi: 10.1093/infdis/jiu338. Epub 2014 Jun 16.
Individuals who are heterozygous for the CCR5-Δ32 mutation provide a natural model to examine the effects of reduced CCR5 expression on human immunodeficiency virus (HIV) persistence. We evaluated the HIV reservoir in 18 CCR5-Δ32 heterozygotes and 54 CCR5 wild-type individuals during suppressive antiretroviral therapy. Cell-associated HIV RNA levels (P=.035), RNA to DNA transcriptional ratios (P=.013), and frequency of detectable HIV 2-long terminal repeat circular DNA (P=.013) were significantly lower in CD4+ T cells from CCR5-Δ32 heterozygotes. Cell-associated HIV RNA was significantly correlated with CCR5 surface expression on CD4+ T cells (r2=0.136; P=.002). Our findings suggest that curative strategies should further explore manipulation of CCR5.
携带CCR5-Δ32突变杂合子的个体为研究CCR5表达降低对人类免疫缺陷病毒（HIV）持续存在的影响提供了一个天然模型。我们评估了18名CCR5-Δ32杂合子和54名CCR5野生型个体在接受抑制性抗逆转录病毒治疗期间的HIV储存库情况。在CCR5-Δ32杂合子的CD4+ T细胞中，细胞相关HIV RNA水平（P = 0.035）、RNA与DNA转录比率（P = 0.013）以及可检测到的HIV 2-长末端重复序列环状DNA频率（P = 0.013）均显著较低。细胞相关HIV RNA与CD4+ T细胞上的CCR5表面表达显著相关（r2 = 0.136；P = 0.002）。我们的研究结果表明，治愈策略应进一步探索对CCR5的调控。
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